Colchiceine, N-deacetyl-N-methyl- 去甲秋水仙碱

CAS 518-11-6 MFCD01736982

化学结构图

518-11-6
SMILES: CNC1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(O)c(=O)cc21

化学属性

Mol. FormulaC₂₀H₂₃NO₅
Mol. Weight357.4
Melting Point120-122°C
Boiling Point

别名和识别编码

Chemical NameColchiceine, N-deacetyl-N-methyl-
MDL NumberMFCD01736982
CAS Number518-11-6
Chemical Name Translation去甲秋水仙碱
InChIKeyATWWYGQDYGSWQA-UHFFFAOYSA-N
Synonym Benzo(a)heptalen-9(5H)-one, Demecolceine
PubChem Substance ID235315
InChIInChI=1S/C20H23NO5/c1-21-14-7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12-6-8-15(22)16(23)10-13(12)14/h6,8-10,14,21H,5,7H2,1-4H3,(H,22,23)/t14-/m0/s1
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安全信息

RTECSGH0600000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957

Storage condition -20

系列性分类

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