Progabide 普罗加比

CAS 62666-20-0 MFCD01740869

化学结构图

62666-20-0
SMILES: NC(=O)CCC/N=C(\C1C=C(F)C=CC=1O)/C1C=CC(Cl)=CC=1

化学属性

Mol. FormulaC17H16ClFN2O2
Mol. Weight335

别名和识别编码

Chemical NameProgabide
CAS Number62666-20-0
Synonym 4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide Butyramide,
Chemical Name Translation普罗加比
Wiswesser Line NotationZV3NUYR DG&R BQ EF
Beilstein Registry Number2339306
MDL Number
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

相关文献及参考

  • Johno, I., et al.: J. Pharm. Sci., 71, 633 (1982),
  • Shestakova., et al.: Bull. Exp. Biol. Med., 137, 255 (2004),

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 655 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - adrenal cortex tumors
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985

RTECSEJ3500970 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches
   Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036)  V.1-    1983-  Volume(issue)/page/year: 3,203,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4094992

系列性分类

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