(Z)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE (Z)-N-(4-羟基-3-甲氧基苄基)-8-甲基-6-壬烯酰胺

CAS 25775-90-0 MFCD00209942

化学结构图

25775-90-0
SMILES: COC1C=C(CNC(=O)CCCC/C=C/C(C)C)C=CC=1O

化学属性

Mol. FormulaC18H27NO3
Mol. Weight305

别名和识别编码

Chemical Name(Z)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE
CAS Number25775-90-0
Synonym Zucapsaicin Civamide N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide (Z)- (Z)-8-Methyl-N-vanillyl-6-nonenamide (Z)-Capsaicin (6Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Beilstein Registry Number4261852
Chemical Name Translation(Z)-N-(4-羟基-3-甲氧基苄基)-8-甲基-6-壬烯酰胺
MDL Number
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.

相关文献及参考

  • Artursson., et al.: J. Pharma. Sci., 73, 1507 (1984),
  • Fu., et al.: Pharma. Res., 2000, 17, 100 (2000),

安全信息

RTECSRA8540000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 36,2595,1993

系列性分类

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