S-(2-((3-Aminopropyl)Amino)Ethyl)O,O-DihydrogenPhosphorothioateTrihydrate S-(2-((3-氨基丙基)氨基)乙基)O,O-二氢硫代磷酸三水合物
CAS 112901-68-5 MFCD00233058
化学结构图
SMILES: NCCCNCCSP(O)(O)=O
化学属性
| Mol. Formula | C5H15N2O3PS |
|---|---|
| Mol. Weight | 214.22 |
别名和识别编码
| Chemical Name | S-(2-((3-Aminopropyl)Amino)Ethyl)O,O-DihydrogenPhosphorothioateTrihydrate |
|---|---|
| Synonym | Amifostine |
| MDL Number | MFCD00233058 |
| PubChem Substance ID | 24278231 |
| Chemical Name Translation | S-(2-((3-氨基丙基)氨基)乙基)O,O-二氢硫代磷酸三水合物 |
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分类
- {SNA} A-AM, Antioxidants and Cytoprotectants, Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress, Therapy Adjuncts
相关文献及参考
- [2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.
- [3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.
- [4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.
- [5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.
- [1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.
- [1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.
- [2]. John R Kouvaris, et al. Amifostine: the first selective-
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
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