3-Cyclohexene-1-carboxylic acid,2-(dimethylamino)-1-phenyl-, ethyl ester,hydrochloride, trans-(+-)-

CAS 27107-79-5 MFCD02684014

化学结构图

27107-79-5
SMILES: O.Cl.CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)C1C=CC=CC=1 |&1:7,12|

化学属性

Mol. FormulaC17H23NO2.ClH
Mol. Weight309.87

别名和识别编码

Chemical Name3-Cyclohexene-1-carboxylic acid,2-(dimethylamino)-1-phenyl-, ethyl ester,hydrochloride, trans-(+-)-
CAS Number27107-79-5
Synonym dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaethylester HCl dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid (1R,2S)-rel-
Wiswesser Line NotationL6UTJ CN1&1 DVO2 DR &GH
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分类

  • Amines
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • This is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.

相关文献及参考

  • Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970),
  • Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983),
  • Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),

安全信息

RTECSGW4375000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,977,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 437 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,977,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,977,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 490 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1450 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,983,1970

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