LY294002 2-吗啉代-8-苯基色酮

CAS 154447-36-6 MFCD00270881

化学结构图

154447-36-6
SMILES: O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12

化学属性

Mol. FormulaC19H17NO3
Mol. Weight307
Melting Point182.0-186.0

别名和识别编码

Chemical NameLY294002
Synonym 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 29400 LY 294002 LY 294002, 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran LY-294002 LY294002
MDL NumberMFCD00270881
PubChem Substance ID3973
CAS Number154447-36-6
Chemical Name Translation2-吗啉代-8-苯基色酮
Beilstein Registry Number8156139
Reaxys-RN8156139
LabNetwork Molecule IDLN01291396
InChIInChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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分类

  • {SNA} Autophagy, Autophagy In
  • {SNA} Autophagy, Autophagy Inhibitors, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Inositol Phosphates, Kinase/Phosphatase Biology, L, Lipids in Cell Signaling, P to Q, PI3K-Akt-mTOR Enzyme Regulators, Phosphatidylinositol 3-kinase, Phosphatidylinositol 3-kinase (PI3K), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Small Molecules for Stem Cell Biology, 干细胞生物学, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节, 酶、抑制剂和底物

相关文献及参考

  • Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269 , 5241, (1994) 摘要
  • Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15 , 5256-5267, (1996) 摘要
  • Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154 , 2413-2422, (1995) 摘要
  • Bulat, N., et al., LDLs Stimulate P38 MAPKs And Wound Healing Through SR-BI Independently Of Ras And PI3 Kinase. J. Lipid Res. 50 , 81-9, (2009) 摘要
  • Petersen, S.L., et al., Overcoming Cancer Cell Resistance To Smac Mimetic Induced Apoptosis By Modulating CIAP-2 Expression. Proc. Natl. Acad. Sci. U. S. A. 107 , 11936-41, (2010) 摘要
  • Kolegraff, K., et al., Loss Of Desmocollin-2 Confers A Tumorigenic Phenotype To Colonic Epithelial Cells Through Activation Of Akt/β-catenin Signaling Mol. Biol. Cell 22 , 1121-1134, (2011) 摘要
  • Dutta, D., et al., Self-renewal Versus Lineage Commitment Of Embryonic Stem Cells: Protein Kinase C Signaling Shifts The Balance. Stem Cells 29 , 618-28, (2011) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S25 Avoid contact with eyes 避免眼睛接触;
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
Storage condition <0°C

系列性分类


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