1-alpha-H,5-alpha-H-Tropane,3-alpha-((p-chloro-alpha-phenylbenzyl)oxy)-,hydrochloride

CAS 14008-79-8 MFCD00274032

化学结构图

14008-79-8
SMILES: Cl.CN1[C@@H]2C[C@H](C[C@H]1CC2)OC(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:3,5,7|

化学属性

Mol. FormulaC21H24ClNO.ClH
Mol. Weight378.37

别名和识别编码

Chemical Name1-alpha-H,5-alpha-H-Tropane,3-alpha-((p-chloro-alpha-phenylbenzyl)oxy)-,hydrochloride
MDL NumberMFCD00274032
Synonym 3-alpha-((p-Chloro-alpha-phenylbenzyl)oxy)-1-alpha-H,5-alpha-H-tropane
CAS Number14008-79-8
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安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
RTECSYM3055500
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 174 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 114,192,1955

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 114,192,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 114,192,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Vo

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