1(2H)-Naphthalenone,3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride, (-)-

CAS 27912-14-7 MFCD00274579

化学结构图

27912-14-7
SMILES: Cl.CC(C)(C)NC[C@@H](O)COC1=CC=CC2C(=O)CCCC=21

化学属性

Mol. FormulaC17H25NO3.ClH
Mol. Weight327.89

别名和识别编码

Chemical Name1(2H)-Naphthalenone,3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride, (-)-
Synonym Vistagan W 7000A Betagan Levobunolol hydrochloride Gotensin l-Bunolol hydrochloride (-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride
CAS Number27912-14-7
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,353,1992

RTECSQK4402500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New
   York, Raven Press, 1980  Volume(issue)/page/year: -,317,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 435 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year:
   17,373,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year:
   17,373,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year:
   17,373,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS

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