(4-Formyl-5-Hydroxy-6-Methylpyridin-3-Yl)Methyl Dihydrogen Phosphate (4-甲酰基-5-羟基-6-甲基吡啶-3-基)甲基二氢磷酸酯

CAS 54-47-7 MFCD00054477

化学结构图

54-47-7
SMILES: CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O

化学属性

Mol. Weight247.14
Mol. FormulaC8H10NO6P
Melting Point140-143 °C

别名和识别编码

Wiswesser Line NotationT6NJ B1 CQ DVH E1OPQQO
Chemical Name(4-Formyl-5-Hydroxy-6-Methylpyridin-3-Yl)Methyl Dihydrogen Phosphate
Synonym Pyridoxal phosphate {hazard_com} Phosphoridoxal coenzyme Piodel Pydoxal Pyridoxal 5-phosphate Pyridoxal P Pyridoxal-5'-phosphate Pyridoxaldehyde phosphate Pyridoxyl phosphate Pyromijin Sechvitan Vitahexin P Vitazechs {} {hazard_com} Phosphopyridoxal {} {} {hazard_com} Pal-P {} {} {} {hazard_com} PLP {} {} {} {} {hazard_com} Hexermin P {} {} {} {} {} {hazard_com} HI-Pyridoxin {} {} {} {} {} {} {hazard_com} Codecarboxylase {} {} {} {} {} {} {} {hazard_com} Biosechs {} {} {} {} {} {} {} {} {hazard_com} Apolon B6 {} {} {} {} {} {} {} {} {} {hazard_com} 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
CAS Number54-47-7
Chemical Name Translation(4-甲酰基-5-羟基-6-甲基吡啶-3-基)甲基二氢磷酸酯
MDL NumberMFCD00006333
Reaxys-RN234749
Merck Number7979
PubChem Substance ID87565509
LabNetwork Molecule IDLN00199158
Canonical SMILESO=CC1=C(O)C(C)=NC=C1COP(O)(O)=O
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相关文献及参考

  • [2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.
  • [1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.
  • [1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.
  • [2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

安全信息

RTECSUV1208000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,643,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,643,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,643,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,643,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 34,530,1975

GHS Symbol
WGK Germany3
Safety Statements
Precautionary statements
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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