22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv. 万古霉素

CAS 1404-90-6 MFCD05664587

化学结构图

1404-90-6
SMILES: CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O

化学属性

Mol. FormulaC66H75Cl2N9O24
Mol. Weight1449
Melting Point274

别名和识别编码

Chemical Name22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv.
MDL NumberMFCD05664587
Chemical Name Translation万古霉素
Synonym AB-Vancomycin Diatracin Hydrochloride, Vancomycin Sulfate, Vancomycin VANCO-cell VANCOMYCIN Vanco Azupharma Vanco-saar Vancocin Vancocin HCl Vancocine Vancomicina Abbott Vancomicina Chiesi Vancomicina Combino Phar Vancomicina Norman Vancomycin Vancomycin (base and/or unspecified salts) Vancomycin Hexal Vancomycin Hydrochloride Vancomycin Lilly Vancomycin Phosphate (1:2) Vancomycin Phosphate (1:2), Decahydrate Vancomycin Sulfate Vancomycin-ratiopharm Vancomycine Dakota 万古霉素
CAS Number1404-90-6
EC Number215-772-6
LabNetwork Molecule IDLN01342348
PubChem Substance ID14969
InChIInChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1
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安全信息

RTECSYW4375000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 43,913,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 15 mg/kg/90M-C
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   313,756,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : I

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Multiple routes
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 30 mg/kg/2D-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   115,410,1991

TYPE OF TEST            : TDLo - Lowest published

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 170 mg/kg/19D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   CMAJAX Canadian Medical Association Journal.  (Canadian Medical Assoc., POB
   8650, Ottawa, ON K1G 0G8, Canada)  V.1-    1911-  Vo

Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P302
  • P302+P352
  • P304 IF INHALED: 如果吸入
  • P304+P340
  • P304+P341
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P313 Get medical advice/attention. 获取医疗咨询/就医
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333 If skin irritation or rash occurs: 如果发生皮肤刺激或皮疹：
  • P333+P313
  • P342 If experiencing respiratory symptoms: 如果出现呼吸症状：
  • P342+P311
  • P342+P316
  • P352 Wash with plenty of soap and water. 用大量肥皂和水清洗。
  • P362+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
GHS Symbol
Signal word Danger

其他信息

  • MOL 文件:1404-90-6.mol
  • 用途二:为窄谱抗生素，仅对革兰阳性菌有效，如溶血性链球菌、肺炎球菌、淋球菌及肠球菌等均属敏感，对耐药金葡菌本品尤为敏感。其作用机制是抑制细菌细胞壁的合成，它主要和细菌细胞壁结合，而使某些氨基酸不能进入细胞壁的糖肽中。 敏感革兰阳性菌所致菌血症、心内膜炎、骨髓炎、肺炎、肺脓肿、软组织感染、脑膜炎等。口服用于难辨梭菌所致伪膜性肠炎。
  • 用途一:万古霉素通过抑制细菌的生长和繁殖来杀死细菌。这种药物通过干扰细菌细胞壁结构中的一种关键组分来干扰细胞壁的合成，抑制细胞壁中磷脂和多肽的生成。万古霉素主要用在四个方面的感染治疗：首先是耐药菌感染的治疗；另外也用在难辨梭菌酿成的抗生素耐药性的伪膜性肠炎的治疗；万古霉素还可以用于治疗结肠炎和肠道炎症；万古霉素还经常用于安装心脏导管、静脉导管等装置时的预防感染。万古霉素可以单独用药，也可以联合用药。
  • 毒害物质数据:1404-90-6(Hazardous Substances Data)
  • 产品类别:抗生素类抗感染原料药
  • 外观:白色或苍白色晶体粉末。

系列性分类

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