(E)-1-Methyl-2-(2-(Thiophen-2-Yl)Vinyl)-1,4,5,6-Tetrahydropyrimidine 4,4’-Methylenebis(3-Hydroxy-2-Naphthoate) (E)-1-甲基-2-(2-(噻吩-2-基)乙烯基)-1,4,5,6-四氢嘧啶-4,4’-亚甲基双(3-羟基-2-萘甲酸)
CAS 22204-24-6 MFCD00072037
化学结构图
SMILES: CN1CCCN=C1/C=C/C1=CC=CS1.OC(=O)C1C=C2C=CC=CC2=C(CC2=C3C=CC=CC3=CC(=C2O)C(O)=O)C=1O
化学属性
| Mol. Weight | 594.68 |
|---|---|
| Mol. Formula | C11H14N2S · C23H16O6 |
| Melting Point | 266-267 ºC |
| Solubility | <0.1 G/100 ML AT 19 ºC |
别名和识别编码
| CAS Number | 22204-24-6 |
|---|---|
| Chemical Name | (E)-1-Methyl-2-(2-(Thiophen-2-Yl)Vinyl)-1,4,5,6-Tetrahydropyrimidine 4,4’-Methylenebis(3-Hydroxy-2-Naphthoate) |
| Synonym | ######## 1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid) Antiminth Pyrantel embonate Combantrin Pyrantel embonate 含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(2-[2-噻吩基]乙烯基)-1,4,5,6-四氢嘧啶化合物 Pyrantel pamoate 双羟萘酸噻嘧啶 含 4,4′-亚甲基双(3-羟基-2-萘甲酸) 的 1-甲基-2-(2-[2-噻吩基]乙烯基)-1,4,5,6-四氢嘧啶化合物 |
| EC Number | 244-837-1 |
| Wiswesser Line Notation | L66J CQ DVQ B1- BL66J CQ DVQ &T6N CN AUTJ C1 B1U1-BT5SJ |
| Chemical Name Translation | (E)-1-甲基-2-(2-(噻吩-2-基)乙烯基)-1,4,5,6-四氢嘧啶-4,4’-亚甲基双(3-羟基-2-萘甲酸) |
| MDL Number | MFCD00072037 |
| PubChem Substance ID | 24898655 |
| Beilstein Registry Number | 9034755 |
| LabNetwork Molecule ID | LN01302173 |
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分类
- Pharmaceuticals
- Heterocycles
- Intermediates & Fine Chemicals
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Spectrum of Activity, 抗生素, 生化试剂
- Aromatics
产品应用
- An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, she
相关文献及参考
- Becher, A.M. et al.: Vet. Parasitol., 171, 116 (2010); Barr, S.C. et al.: Am. J. Vet. Res., 59, 1134 (1998);
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >24 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >24 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,305,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATI
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 5 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,79,1987
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 20 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,79,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 1-6 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : VMJGEA Veterinary Medical Journal Giza. (Cairo University, Faculty of Veterinary Medicine, Giza, Egypt) V.37- 1989- Volume(issue)/page/year: 41,23,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 180 mg/kg SEX/DURATION : female 1-6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : VMJGEA Veterinary Medical Journal Giza. (Cairo University, Faculty of Veterinary Medicine, Giza, Egypt) V.37- 1989- Volume(issue)/page/year: 41,23,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : VMJGEA Veterinary Medical Journal Giza. (Cairo University, Faculty of Veterinary Medicine, Giza, Egypt) V.37- 1989- Volume(issue)/page/year: 41,23,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 140 mg/kg SEX/DURATION : female 7-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : VMJGEA Veterinary Medical Journal Giza. (Cairo University, Faculty of Veterinary Medicine, Giza, Egypt) V.37- 1989-
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