Propionanilide,N-(4-(methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)-, citrate

CAS 60561-17-3 MFCD00072116

化学结构图

60561-17-3
SMILES: CCC(=O)N(C1C=CC=CC=1)C1(COC)CCN(CCC2=CC=CS2)CC1.OC(CC(O)=O)(CC(O)=O)C(O)=O

化学属性

Mol. FormulaC22H30N2O2S.C6H8O7
Mol. Weight578.74

别名和识别编码

Chemical NamePropionanilide,N-(4-(methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)-, citrate
CAS Number60561-17-3
Synonym R 33800 Sufenta Sufentanil Forte N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropionamide citrate N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl, propanamide 2-Hydroxy-1,2,3-propanetricarboxylate N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide R 30730 Citrate Salt Sufentanyl Citrat
Wiswesser Line NotationT6NTJ DNR&V2 D1O1 A2- BT5SJ &QV1U1VQ -T
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Potent derivative of Fentanyl. Analgesic (narcotic).

相关文献及参考

  • Gillespie, T.J., et al.: J. Anal. Toxicol., 5, 133 (1981),
  • Leyson, J.E., et al.: Eur. J. Pharmacol., 87, 209 (1983),
  • Michaels, M., et al.: J. Pharm. Pharmacol., 35, 86 (1983),

安全信息

Restrict 精麻类化学品 {} 麻醉药品
RTECSUE5295000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2777 ng/kg/3M-C
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AACRAT Anesthesia and Analgesia (New York).  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.36-    1957-
   Volume(issue)/page/year: 65,703,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17900 ug/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,1548,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1200 ng/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AACRAT Anesthesia and Analgesia (New York).  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.36-    1957-
   Volume(issue)/page/year: 66,91,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1 ug/kg/20H-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANASAB Anaesthesia.  (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1
   7DX, UK)  V.1-    1946-  Volume(issue)/page/year: 42,665,1987

TYPE OF TEST            :

系列性分类

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