GGTI-2133

CAS N/A MFCD07776925

化学结构图

N/A
SMILES: CC(C)C[C@H](NC(=O)C1=CC=C(C=C1C1C=CC=C2C=CC=CC2=1)NCC1=CNC=N1)C(O)=O.OC(=O)C(F)(F)F

化学属性

Mol. FormulaC27H28N4O3· C2HF3O2
Mol. Weight570.56
Melting Point103-118.5 °C

别名和识别编码

Chemical NameGGTI-2133
Synonym GGTI-2133 N-[[4-(Imidazol-4-yl)methylamino]-2-(1-naphthyl)benzoyl]leucine trifluoroacetate salt
PubChem Substance ID24724491
MDL NumberMFCD07776925
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G, Geranylgeranyl transferase I, M
  • {SNA} Bioactive Small Molecule Alphabetical Index, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G, Geranylgeranyl transferase I, 生化试剂, 生物活性小分子, 甲羟戊酸途径中的抑制剂和激活剂, 癌症中的甲羟戊酸途径, 癌症代谢, 癌症研究, 细胞生物学,

相关文献及参考

  • , Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. J. Med. Chem. 42 , 1333-1340, (1999) 摘要
  • , Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg. Med. Chem. 6 , 293-299, (1998) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Geranylgeranyl transferase I - D to K

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