Reversine N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺

CAS 656820-32-5 MFCD07784513

化学结构图

656820-32-5
SMILES: c1nc2nc(Nc3ccc(N4CCOCC4)cc3)nc(NC3CCCCC3)c2[nH]1

化学属性

Mol. FormulaC21H27N7O
Mol. Weight393.49
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameReversine
Synonym 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine Reversine Reversine.
MDL NumberMFCD07784513
PubChem Substance ID24724590
CAS Number656820-32-5
Chemical Name TranslationN6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
FormulaC21H27N7O
IUPAC NameN6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine
InChIKeyZFLJHSQHILSNCM-UHFFFAOYSA-N
InChIInChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
Canonical SMILESC12=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC(NC5CCCCC5)=C1NC=N2
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分类

  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, Neuroscience, Neurotransmission, Neurotransmitters, R, Small Molecules for Stem Cell Biology, 干细胞生物学, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neuroscience, Neurotransmission, Neurotransmitters, R, Small Molecules for Stem Cell Biology, Stem Cell Biology

产品应用

  • Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors.

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. R - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Adenosines/P2 Nucleotide Receptors (Purinergics) - Neurotransmitters
  8. Antagonists - Adenosines/P2 Nucleotide Receptors (Purinergics)
  1. Medical Research Areas
  2. Cell Cycle
  3. Aurora Kinase

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