((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold ((2S,3R,4S,5R,6R)-3,4,5-三乙酰氧基-6-(乙酰氧基甲基)四氢-2H-吡喃-2-硫基)(三乙基膦)金

CAS 34031-32-8 MFCD00080759

化学结构图

34031-32-8
SMILES: CC(=O)O[C@@H]1[C@@H](COC(C)=O)O[C@@H](S[Au]=P(CC)(CC)CC)[C@H](OC(C)=O)[C@H]1OC(C)=O

化学属性

Mol. FormulaC20H34AuO9PS
Mol. Weight678.54

别名和识别编码

Chemical Name((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydro-2H-Pyran-2-Thio)(Triethylphosphine)Gold
CAS Number34031-32-8
Synonym Auranofin 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium SKF 39162 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium SKF 39162 Gold, (1-thio-beta-D-glucopyranose [1-(Thio-?S)-?-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold
MDL NumberMFCD00080759
EC Number251-801-9
Chemical Name Translation((2S,3R,4S,5R,6R)-3,4,5-三乙酰氧基-6-(乙酰氧基甲基)四氢-2H-吡喃-2-硫基)(三乙基膦)金
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分类

  • Carbohydrates & Derivatives
  • Sulfur & Selenium Compounds
  • {SA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, I Kappa B Kinase (IKK), Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Kinase/Phosphatase Biology, Prometheus, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, I Kappa B Kinase (IKK), Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Kinase/Phosphatase Biology, Prometheus, Serine/Threonine Kinase Biology, Serine/Threonine Kin

产品应用

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相关文献及参考

  • Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993),
  • Itokazu, M., et al.: Clin. Ther., 17, 60 (1995),
  • Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H301 Toxic if swallowed 吞食有毒
RTECSMD6500000
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 5400 ug/kg/10D-I
TOXIC EFFECTS :
   Behavioral - toxic psychosis
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
REFERENCE :
   ARHEAW Arthritis and Rheumatism.  (Arthritis Foundation, 1314 Spring St.,
   NW, Atlanta, GA 30309) V.1-    1958-  Volume(issue)/page/year: 27,1316,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,1106,1986

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,1106,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 265 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),1,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 41 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,3243,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 179 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),97,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),89,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 358 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   VTPHAK Veterinary Pathology.  (Waverly Press, Inc., POB 64025, Baltimore, MD
   21264)  V.8-    1971-  Volume(issue)/page/year: 15(Suppl 5),97,1978

系列性分类

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