2-Amino-5-Bromo-4-Hydroxy-6-Phenylpyrimidine 2-氨基-5-溴-4-羟基-6-苯基嘧啶

CAS 56741-95-8 MFCD00813905

化学结构图

56741-95-8
SMILES: NC1N=C(O)C(Br)=C(N=1)C1C=CC=CC=1

化学属性

Mol. FormulaC10H8BrN3O
Mol. Weight266.09

别名和识别编码

Chemical Name2-Amino-5-Bromo-4-Hydroxy-6-Phenylpyrimidine
CAS Number56741-95-8
Alfabeta NameAMINOBROMOHYDROXYPHENYLPYRIMIDINE 2546-------
MDL NumberMFCD01689128
Synonym ######## 2-Amino-5-bromo-6-phenyl-4(1H)-pyrimidinone 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone NSC 149027 PNU 54461 U 54461 U 54461S Bropirimine U-54461
Beilstein Registry Number0651807
PubChem Substance ID329825238
Chemical Name Translation2-氨基-5-溴-4-羟基-6-苯基嘧啶
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Aromatics
  • Heterocycles
  • {SNA} B, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • ########

相关文献及参考

  • Akaza, H. et al.: Eur. Urol., 34, 107 (1998); Tei, Y. et al.: Anticancer Res., 22, 1667 (2002); Kassouf, W. et al.: Exp. Rev. Anticancer Ther., 4, 1037 (2004);

安全信息

Warnings IRRITANT
RTECSUW7351300 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   9,567,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 252,239,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 252,221,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 252,221,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 200 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 252,221,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1450 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 35,30A,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   13,87,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 42,55,1990

TYPE OF TEST            : TDLo - Lowest published tox

GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
WGK Germany3
Signal word Warning
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Hazard Codes Xn
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

系列性分类

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