3-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-Dione 3-(2-(4-(4-氟苯甲酰)哌啶-1-基)乙基)喹唑啉-2,4(1H,3H)-二酮

CAS 74050-98-9 MFCD00083392

化学结构图

74050-98-9
SMILES: O=C1C2C=CC=CC=2NC(=O)N1CCN1CCC(CC1)C(=O)C1C=CC(F)=CC=1

化学属性

Mol. FormulaC22H22FN3O3
Mol. Weight395
Melting Point231.0 to 235.0 deg-C

别名和识别编码

Chemical Name3-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-Dione
CAS Number74050-98-9
Synonym 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione Ketensin R 41468
MDL NumberMFCD00083392
Beilstein Registry Number4913068
EC Number277-680-2
Chemical Name Translation3-(2-(4-(4-氟苯甲酰)哌啶-1-基)乙基)喹唑啉-2,4(1H,3H)-二酮
Reaxys-RN4913068
Merck Number5296
PubChem Substance ID253661148
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An antihypertensive, with affinity for multiple GPCR receptors.

相关文献及参考

  • [2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.
  • [3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76.
  • [4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.
  • Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009),
  • Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009),
  • Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009),
  • [1].
  • [1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73.

安全信息

WGK Germany3
RTECSVA1411190
GHS Symbol
Signal word
Safety Statements
Risk Statements
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Storage condition 0-10°C

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. 5-HT Receptor  (5-羟色胺受体)

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