Isonipecotamide,1-(3-(2-(methylsulfonyl)phenothiazin-10-yl)propyl)-

CAS 14008-44-7 MFCD00837528

化学结构图

14008-44-7
SMILES: CS(=O)(=O)C1=CC2=C(C=C1)SC1C=CC=CC=1N2CCCN1CCC(CC1)C(N)=O

化学属性

Mol. FormulaC22H27N3O3S2
Mol. Weight445.64

别名和识别编码

Chemical NameIsonipecotamide,1-(3-(2-(methylsulfonyl)phenothiazin-10-yl)propyl)-
CAS Number14008-44-7
Synonym 2-Methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine 10-(3-(4-Carbamoylpiperidine)propyl)-2-(methanesulfonyl)phenothiazine 1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)-4-piperidinecarboxamide EXP 999 Metopimazine Phenothiazine, 10-(3-(4'-carbamoylpiperidino)propyl)-2-methylsulfonyl- 1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)isonipecotamide 1-(3-(2-(Methylsulfonyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinecarboxamide 4-Piperidinecarboxamide, 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
Wiswesser Line NotationT C666 BN ISJ ESW1 B3- AT6NTJ DVZ
Beilstein Registry Number4278585
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Amines
  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Metopimazine (MPZ) is used to prevent emesis during chemotherapies.

相关文献及参考

  • Catz, P., et al.: Int. J. Pharm., 58, 93

安全信息

RTECSNS5075000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 1,9

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 11,561,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - tremor
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CP

系列性分类

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