1-Ethyl-6-Fluoro-7-(4-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid 1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸

CAS 70458-92-3 MFCD00865015

化学结构图

70458-92-3
SMILES: CN1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=CN2CC)C(O)=O

化学属性

Mol. FormulaC17H20FN3O3
Mol. Weight333.40

别名和识别编码

Chemical Name1-Ethyl-6-Fluoro-7-(4-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
Wiswesser Line NotationT66 BN VVJ B2 DVQ HF I- AT6N DNTJ D1
Synonym 1584RB AM-725 Pefloxacin 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid AM 725 Pefloxacine
CAS Number70458-92-3
Beilstein Registry Number0567618
Chemical Name Translation1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
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安全信息

RTECSVB2002000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4530930

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #0047005

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1714 mg/kg/21W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
   Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 340,126,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 343 mg/kg/30D-I
TOXIC EFFECTS :
   Musculoskeletal - joints
   Musculoskeletal - other changes
REFERENCE :
   DRSAEA Drug Safety.  (Adis International Ltd.,  Private Bag 65901, Mairangi
   Bay, Auckland 10, New Zealand)  V.5-    1990-  Volume(issue)/page/year:
   7,310,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Behavioral -

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 780 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 221,263,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 gm/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 25,475,1983

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物

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