N’-Benzyl-5-Methylisoxazole-3-Carbohydrazide N’-苄基-5-甲基异噁唑-3-酰肼
CAS 59-63-2 MFCD00865409
化学结构图
SMILES: Cc1cc(C(=O)NNCc2ccccc2)no1
化学属性
| Mol. Formula | C12H13N3O2 |
|---|---|
| Mol. Weight | 231.25 |
别名和识别编码
| Chemical Name | N’-Benzyl-5-Methylisoxazole-3-Carbohydrazide |
|---|---|
| CAS Number | 59-63-2 |
| Synonym | BMIH 3-(N-Benzylhydrazinocarbonyl)-5-methylisoxazole Isocarboxazide 1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine Marplan Isocarboxazid Isocarboxazid 5-methyl-3-isoxazole-carboxylic acid 2-benzylhydrazide Isocarbonazid 1 - 苄基-2 - （5 - 甲基-3 - 异恶唑羰基）肼 Isocarbossazide Enerzer Ro 5-0831/1 5-Methyl-3-isoxazole-carboxylic Acid 2-Benzylhydrazide Ro-5-0831 5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide Ro 5-0831 Marplon Benazide N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3 Isocarboxyzid Maraplan |
| MDL Number | MFCD00865409 |
| Chemical Name Translation | N’-苄基-5-甲基异噁唑-3-酰肼 |
| Wiswesser Line Notation | T5NOJ C1 EVMM1R |
| Beilstein Registry Number | 0201295 |
| EC Number | 200-438-4 |
| PubChem Substance ID | 3759 |
| InChI | InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16) |
| LabNetwork Molecule ID | LN01287895 |
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分类
- Pharmaceuticals
- {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Isoxazoles
- Intermediates & Fine Chemicals,
- Inhibitors
产品应用
- Monoamine oxidase inhibitor. Antidepressant.
相关文献及参考
- Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 295 (1973),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 39,141,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 80,626,1959
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >40 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 80,626,1959
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED :
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 193 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 80,626,1959
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 322 mg/kg/5D (Continuous) REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 49 mg/kg REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 125 ug/well REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 350 umol/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1469,1981
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 100 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : CAJPBD Proceedings of the Congenital Anomalies Research Association of Japan. (Kyoto, Japan) No.1- 1961- Volume(issue)/page/year: 3,2,1963
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 130 mg/kg SEX/DURATION : female 10-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,493,1985
GHS Symbol
- P301+P310
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
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