4-Chloro-N-(2,6-Dimethylphenyl)-2-Hydroxy-5-Sulfamoylbenzamide 4-氯-N-(2,6-二甲基苯基)-2-羟基-5-氨磺酰基苯甲酰胺

CAS 14293-44-8 MFCD00865927

化学结构图

14293-44-8
SMILES: CC1C=CC=C(C)C=1NC(=O)C1=CC(=C(Cl)C=C1O)S(N)(=O)=O

化学属性

Mol. FormulaC15H15ClN2O4S
Mol. Weight354.83
Melting Point255-256 ºC

别名和识别编码

Chemical Name4-Chloro-N-(2,6-Dimethylphenyl)-2-Hydroxy-5-Sulfamoylbenzamide
CAS Number14293-44-8
Synonym Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy- BEI-1293 Xipamide 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide Aquaphor Diurex 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide Chronexan Aquaphor (diuretic) Xipamid 4-Chlor-5-sulfamoyl-2',6'-salicyloxylidid 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide Lumitens
EC Number238-216-4
Beilstein Registry Number2778357
Chemical Name Translation4-氯-N-(2,6-二甲基苯基)-2-羟基-5-氨磺酰基苯甲酰胺
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Xipamide is a diuretic and antihypertensive agent.

相关文献及参考

  • Wagieh, N., et al.: Drug Test. Anal., 2, 113 (2010),
  • Prado-Prado, F., et al.: Bioorg. Med. Chem., 18, 2225 (2010),
  • Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),

安全信息

RTECSVO6920000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,245,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,245,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,245,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,245,1975

TYPE OF TE

系列性分类

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