Tiotropium bromide 噻托溴铵
CAS 136310-93-5 MFCD00867027
化学结构图
SMILES: [Br-].C[N+]1(C)[C@@H]2C[C@H](C[C@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1
化学属性
| Mol. Formula | C19H22BrNO4S2 |
|---|---|
| Mol. Weight | 472 |
别名和识别编码
| Chemical Name | Tiotropium bromide |
|---|---|
| CAS Number | 136310-93-5 |
| Synonym | (1?,2?,4?,5?,7?)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide |
| Chemical Name Translation | 噻托溴铵 |
| MDL Number | MFCD00867027 |
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分类
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds,
产品应用
- Muscarinic receptor antagonist. Bronchodilator.
相关文献及参考
- [2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35.
- [3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14.
- [4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20.
- [5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62.
- Donohue, J. F., et al.: Chest, 122, 47 (2002),
- Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994),
- Profita, M., et al.: Allergy, 60, 1361 (2005),
- [1]. Barnes PJ. Tiotropium
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