Fluocortolone

CAS 152-97-6 MFCD00867463

化学结构图

152-97-6
SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

化学属性

Mol. FormulaC22H29FO4
Mol. Weight376

别名和识别编码

Chemical NamePregna-1,4-diene-3,20-dione,6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-
CAS Number152-97-6
Synonym 6-alpha-Fluoro-16-alpha-methylpregna-1,4-diene-11-beta,21-diol-3,20-dione Flucortolone Fluorcortolone Fluocortolone 16?-Methyl-6?-fluoro-?1,4-pregnadien-11?,21-diol-3,20-dione (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-Fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (6?,11?,16?)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 6-alpha-Fluoro-16-alpha-methyl-1-dehydrocorticosterone Fluocortolon 6-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione 6-alpha-Fluoro-16-alpha-methyl-delta(sup
EC Number205-811-5
Chemical Name Translation
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1Q G1 LF
Beilstein Registry Number3122594
PubChem Substance ID9053
InChIInChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1
MDL Number
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • Glucocorticoid.

相关文献及参考

  • Breuer, et al.: Arzneim.-Forsch., 15, 50 (1965),
  • Domenico, et al.: Arzneim.-Forsch., 15, 46 (1965),
  • Gerhards, et al.: Acta Endocrinol., 68, 98 (1971),

安全信息

RTECSTU3832500 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 30 mg/kg
SEX/DURATION            : female 7-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 10,151,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., s

系列性分类

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