Etonogestrel 依托孕烯

CAS 54048-10-1 MFCD00867863

化学结构图

54048-10-1
SMILES: CC[C@]12CC(=C)[C@@H]3[C@H]4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C#C

化学属性

Mol. FormulaC22H28O2
Mol. Weight324.46

别名和识别编码

Chemical NameEtonogestrel
CAS Number54048-10-1
Synonym (17-alpha)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one (17?)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one (17α)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one (17α)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one 3-Keto-desogestrel 3-Oxo-desogestrel 13-Ethyl-11-methylene-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one 17-Ethinyl-17-beta-hydroxy-18-methyl-11-methylene-4-estren-3-one 3-Keto-desogestrel 3-Ketodesogestrel 3-Oxo-desogestrel 3-Oxodesogestrel Implanon ORG 3236 Org-3236
EC Number258-936-2
Chemical Name Translation依托孕烯
MDL NumberMFCD00867863
PubChem Substance ID329825358
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, New Products, Progesterone, Steroid Hormones
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, E, Hormones, Progesterone, Stero

产品应用

  • A biologically active metabolite of Desogestrel.

相关文献及参考

  • Croxatto, H.B., et al.: Hum. Reprod., 14, 976 (1999),
  • Edwards, J.E., et al.: Brit. J. Fam. Plan., 24, 3 (1999),
  • Krikun, G., et al., Effects of Etonogestrel Treatment in the Reproductive Organs and Uterine Arteries of Nonoophorectomized Guinea Pigs. Reprod. Sci. Jan 19 , (2012)
  • Moser, C., et al., Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma. Anal. Bioanal. Chem Dec 10 , (2011)
  • Lortlar, N., et al., The long-term effects of progesterone-only contraceptives on endometrium and ovary in rats. Arch. Pathol. 281 , 1051-1059, (2010)

安全信息

GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
WGK Germany3
RTECSJF8290000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 35,459,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 10500 ng/kg
SEX/DURATION            : female 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 17,19,1978

Risk Statements
  • R60 May impair fertility 可能降低生殖能力
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Progesterone - Steroid Hormones

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