Heptanoic acid,7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)-

CAS 57574-09-1 MFCD00868087

化学结构图

57574-09-1
SMILES: OC(=O)CCCCCCNC1C2C=CC=CC=2CCC2C=CC=CC=21

化学属性

Mol. FormulaC22H27NO2
Mol. Weight337.50

别名和识别编码

Chemical NameHeptanoic acid,7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)-
CAS Number57574-09-1
Synonym Amineptine 7-[(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]heptanoic Acid Survector 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid
Beilstein Registry Number2170218
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分类

  • Amines
  • Aromatics
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Amineptine is used as an atypical tricyclic antidepressant. Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine.

相关文献及参考

  • Vaugeois J.M. et al.: Pharmacol. Biochem. Behav., 63, 285 (1999); Chanelet, J. et al.: Pharmatherapeutica, 1, 593 (1977); Hall, H. et al.: Acta Pharmacol. Toxicol., 54, 379 (1984);

安全信息

RTECSMJ1970000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 17,37,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 84 mg/kg/2W-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Liver - liver function tests impaired
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   GUTTAK Gut.  (British Medical Journal, Box 560B, Kennebunkport, ME 04046)
   V.1-    1960-  Volume(issue)/page/year: 27,726,1986

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