Carbamic acid, dimethyl-,7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester

CAS 36104-80-0 MFCD00868189

化学结构图

36104-80-0
SMILES: CN(C)C(=O)OC1N=C(C2C=C(Cl)C=CC=2N(C)C1=O)C1C=CC=CC=1

化学属性

Mol. FormulaC19H18ClN3O3
Mol. Weight371.85

别名和识别编码

Chemical NameCarbamic acid, dimethyl-,7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester
CAS Number36104-80-0
Synonym Albego 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Camazepam N,N-Dimethylcarbamic Acid 7-Chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl- B 5333 7-Chloro-1,3-dihydro-3-(N,N-dimethylcarbamoyl)-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Wiswesser Line NotationT67 GNV JN IHJ CG G1 IOVN1&1 KR
Beilstein Registry Number0715180
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Anxiolytic.

相关文献及参考

  • Merlo, L., et al.: Arzneim.-Forsch., 24, 1759 (1974),
  • Carrara, S., et al.: Eur. J. Clin. Pharmacol., 13, 335 (1978),
  • Marcucci, F., et al.: J. Pharm. Sci., 67, 1470 (1978),

安全信息

RTECSEZ9033500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 970 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,2032,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,2029,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,2032,1974

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