(2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone 苯碘达隆

CAS 68-90-6 MFCD00868246

化学结构图

68-90-6
SMILES: CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1

化学属性

Mol. FormulaC17H12I2O3
Mol. Weight518.08
Melting Point167 °C

别名和识别编码

Chemical Name(2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone
CAS Number68-90-6
Synonym Benziodarone {LY} Benziodarone {} {LY} Benziodarone {} {} {LY} Benziodarone {} {} {} {LY} Benziodarone {} {} {} {} {LY} Benziodarone {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benziodarone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Chemical Name Translation 苯碘达隆
Wiswesser Line NotationT56 BOJ C2 DVR DQ CI EI
Beilstein Registry Number1257683
Reaxys-RN1257683
Merck Number1083
MDL NumberMFCD00868246
Canonical SMILESO=C(C1=CC(I)=C(C(I)=C1)O)C2=C(OC3=CC=CC=C23)CC
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A uricosuric drug. It is used to effectively to control hyperuricemia in renal transplantation.

相关文献及参考

  • Lemieux, G. et al.: Am. J. Physiol., 224, 1440 (1973); Zoellner, N. et al.: Arzneim.-Forsch., 21, 1500 (1971); Perez-Ruiz, F. et al.: Nephrol. Dial. Transplant., 18, 603 (2003);

安全信息

RTECSOB1835000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 24,431,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 24,431,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,1388,1965

Hazard Class6.1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
GHS Symbol
UN Number 2811
Signal word
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310+P330
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII
Storage condition

系列性分类

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