2-Azabicyclo(2.2.2)octane,2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-

CAS 57726-65-5 MFCD00870662

化学结构图

57726-65-5
SMILES: CC1=NN=C(O1)C(CCN1C[C@@H]2CC[C@H]1CC2)(C1=CC=CC=C1)C1=CC=CC=C1 |&1:11,14|

化学属性

Mol. FormulaC25H29N3O
Mol. Weight387.57

别名和识别编码

Chemical Name2-Azabicyclo(2.2.2)octane,2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-
Synonym 2-(3,3-Diphenyl-3-(5-methyl-1,3,4-oxadiazol-2-yl)propyl)-2-azabicyclo(2.2.2)octane Searle 27166 Nufenoxole SC 27166 2-(3-(5-Methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl)-2-azabicyclo(2.2.2)octane
Beilstein Registry Number0939075
CAS Number57726-65-5
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安全信息

RTECSCL5629500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 1,1,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 399 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 38,1621,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 258 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 38,1621,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Behavioral - analgesia
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams

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