Halofantrine hydrochloride 盐酸卤泛群

CAS 36167-63-2 MFCD00879136

化学结构图

36167-63-2
SMILES: Cl.CCCCN(CCC(O)C1C=C2C(C=C(Cl)C=C2Cl)=C2C=C(C=CC2=1)C(F)(F)F)CCCC

化学属性

Mol. FormulaC26H31Cl3F3NO
Mol. Weight537

别名和识别编码

Chemical Name9-Phenanthrenemethanol,1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride
CAS Number36167-63-2
Synonym 1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl Halfan 1,3-Dichloro-?-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol 1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride Halofantrine 盐酸盐 Halofantrine hydrochloride WR-171,669 Halofantrino
MDL NumberMFCD00879136
EC Number252-895-4
Chemical Name Translation盐酸卤泛群
Wiswesser Line NotationL B666J DG FG IYQ2N4&4 MXFFF &GH
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, H, Ion Channels, Merck, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, Voltage-gated Ion Channels

产品应用

  • Antimalarial.

相关文献及参考

  • Schmidt, L.H., et al.: Antimicrob. Agents Chemother., 14, 292 (1978),
  • Hines, J.W., et al.: J. Pharm. Sci., 74, 433 (1985),
  • Bryson, H.M., et al.: Drugs, 43, 236 (1992),

安全信息

RTECSSF7790000
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 7143 ug/kg
TOXIC EFFECTS :
   Liver - jaundice, oth

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2050 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ACTRAQ Acta Tropica.  (Schwabe & Co., Steintorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 37,232,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 18 mg/kg/D
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - other changes
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,547,1980

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 72 mg/kg/3D-I
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 341,1054,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 7143 ug/kg
TOXIC EFFECTS :
   Liver - liver function tests impaired
   Kidney, Ureter, Bladder - urine volume decreased
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 120 mg/kg
SEX/DURATION            : female 6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 4,85,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 240 mg/kg
SEX/DURATION            : female 6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 4,85,1984

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Other Sodium Channel Modulators - Sodium Channel Modulators

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