2-amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate 2-氨基-2-(羟甲基)丙烷-1,3-二醇5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸酯

CAS 74103-07-4 MFCD00887595

化学结构图

74103-07-4
SMILES: NC(CO)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1C=CC=CC=1

化学属性

Mol. FormulaC15H13NO3·C4H11NO3
Mol. Weight376.41
Melting Point165.0 to 169.0 deg-C

别名和识别编码

Chemical Name2-amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
CAS Number74103-07-4
Synonym (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt Toradol Dolac Ketanov Ketorol Ketorolac Tris Salt Ketorolac tris salt Ketorolac trometamol Ketorolac tromethamine Lixidol Syntex Tarazyn Toradol Toratex Trometamol Ketorolac
MDL NumberMFCD00887595
PubChem Substance ID253661330
Chemical Name Translation2-氨基-2-(羟甲基)丙烷-1,3-二醇5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-羧酸酯
Reaxys-RN6463165
Merck Number5306
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
  • {SNA} A to C, Application Index, Arachidonic Acid Cascade, Cell Signaling Enzymes, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling, P to Q, Prostaglandin H synthetases 1 (COX-1) and 2 (COX-2), 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • {SA} A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecules,
  • Intermediates & Fine Che

产品应用

  • Ketorolac is an analgesic; anti-inflammatory.

相关文献及参考

  • Etman, M., et al.: Pharm. Technol., 32, 58 (2008),
  • Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008),
  • Cirino, G., et al., Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties. Br. J. Pharmacol. 117 , 1421, (1996) 摘要
  • Tripathi, A., Welch, S.P., Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine. Eur. J. Pharmacol. 278 , 27, (1995) 摘要
  • Laneuville, O., Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271 , 927, (1994) 摘要
  • Michel, R.E., et al., Ketorolac causes the release of methionine-enkephalin in rats. Res. Commun. Mol. Pathol. Pharmacol. 91 , 249, (1996) 摘要
  • Scarlett, J.M., et al., Regulation of Central Melanocortin Signaling by Interleukin-1{beta} Endocrinology 148 , 4217-25, (2007) 摘要
  • Scarlett, J.M., et al., Regulation of Agouti-Related Protein Messenger Ribonucleic Acid Transcription and Peptide Secretion by Acute and Chronic Inflammation Endocrinology 149 , 4837-45, (2008) 摘要
  • Zhang, Y., et al., Crystal Structure Of The Receptor Binding Domain Of The Botulinum C-D Mosaic Neurotoxin Reveals Potential Roles Of Lysines 1118 And 1136 In Membrane Interactions. Biochem. Biophys. Res. Commun. 404 , 407-12, (2011) 摘要
  • Merck 14 ,5306

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T
RTECSUY7759900
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 858 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Lungs, Thorax, or Respiration - dyspnea
   Immunological Including Allergic - anaphylaxis
REFERENCE :
   APHRER Annals of Pharmacotherpy.  (Harvey Whitney Books Co., POB 42696,
   Cincinnati, OH 45242) V. 26-    1992-  Volume(issue)/page/year: 26,1237,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1200 ug/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Lungs, Thorax, or Respiration - bronchiolar constriction
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 87,282,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 19853 ug/kg/12D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubul

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 857 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   32,305,1994

Hazard Class6.1
UN Number 2811
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. K - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Prostaglandin H synthetases 1 (COX-1) and 2 (COX-2) - P to Q
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes

相关产品推荐