(R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Propanoic Acid (R)-3-(3-(4-氟苯基磺酰胺基)-3,4-二氢-1H-咔唑-9(2H)-基)丙酸

CAS 116649-85-5 MFCD00887606

化学结构图

116649-85-5
SMILES: O=C(O)CCn1c2c(c3ccccc31)C[C@H](NS(=O)(=O)c1ccc(F)cc1)CC2

化学属性

Mol. FormulaC21H21FN2O4S
Mol. Weight416

别名和识别编码

Chemical Name(R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Propanoic Acid
CAS Number116649-85-5
Synonym (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid BAY u3405 (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic Acid 3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid BAY u 3405 BAY u 3406 BAY u-3405 BAY u3405 BAY-u 3405 Baynas Ramatroban ramatroban
MDL NumberMFCD00887606
Chemical Name Translation(R)-3-(3-(4-氟苯基磺酰胺基)-3,4-二氢-1H-咔唑-9(2H)-基)丙酸
PubChem Substance ID123879
InChIInChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
LabNetwork Molecule IDLN00196684
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分类

  • Pharmaceuticals
  • {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bayer, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Lipids in Cell Signaling, Other
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bayer, Bioactive Small Molecule Alphabetical Index,

产品应用

  • A thromboxane receptor antagonist for use in the treatment of coronary artery disease.

相关文献及参考

  • [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D 2 -induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.
  • [3]. Haba R, et al. Central CRTH2, a second prostaglandin D 2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.
  • Rahman, M., et al.: Int. Immunopharmacol., 6, 1736 (2006),
  • [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.
  • [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.
  • [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany1
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Bayer - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Prostaglandin Receptor  (前列腺素受体)

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