CKI-7 CKI-7

CAS 1177141-67-1 MFCD00897689

化学结构图

1177141-67-1
SMILES: NCCNS(=O)(=O)C1C=CC(Cl)=C2C=CN=CC=12

化学属性

Mol. FormulaC11H14Cl3N3O2S
Mol. Weight359

别名和识别编码

Chemical NameCKI-7
Synonym CKI-7 dihydrochloride N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
CAS Number1177141-67-1
PubChem Substance ID24724430
MDL NumberMFCD00897689
Chemical Name TranslationCKI-7
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • Bioactive Small Molecules, CI-CY, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, Glycogen Synthase Kinase & Casein Kinase (GSK & CK), Kinase/Phosphatase Biology, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
  • {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Casein Kinase (CK), Glycogen Synthase Kinase & Ca
  • {SNA} Bioactive Small Molecules, CI-CY, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, Glycogen Synthase Kinase & Casein Kinase (GSK & CK), Kinase/Phosphatase Biology, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

相关文献及参考

  • [2]. Mark G. Frattini, et al. Small Molecule Inhibition of Cdc7, a Key Cell Cycle Regulator and Novel Therapeutic Target, Successfully Inhibits Leukemia Cell Growth in Vitro and in Vivo. Blood (2008) 112 (11): 2668.
  • [3]. Chijiwa T, et al. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem. 1989 Mar 25;264(9):4924-7.
  • [4]. Rena G, et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5(1):60-5.
  • Rena, G., et al. , D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO J. Rep. 5 , 60-65, (2004) 摘要
  • [1]. Osakada F, et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009 Sep 1;122(Pt

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Precautionary statements
  • P301+P310
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类


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