Milnacipran Hydrochloride 盐酸米那普仑

CAS 101152-94-7 MFCD00901293

化学结构图

101152-94-7
SMILES: Cl.CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)C1C=CC=CC=1 |&1:8,10|

化学属性

Mol. FormulaC15H23ClN2O
Mol. Weight283
Melting Point181

别名和识别编码

Chemical NameMilnacipran Hydrochloride
CAS Number101152-94-7
Synonym Toledomin Ixel (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride F 2207 Midalcipran Toledomin (1R,2S)-rel-2(Aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide, Monohydrochloride Dalcipran
MDL NumberMFCD00901293
Chemical Name Translation盐酸米那普仑
Reaxys-RN6078861
Merck Number6194
PubChem Substance ID125307702
Beilstein Registry Number6078861
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分类

  • {SNA} Adrenergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cypress Bioscience, M, Neuroscience, Neurotransmission, Neurotransmitters, Other Adrenergics, Other Serotonergics, Serotonergics, 生物活性小分子, 细胞信号转导和神经科学,
  • {SNA} Adrenergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cypress Bioscience, M, Neuroscience, Neurotransmission, Neurotransmitters, Others, Serotonergics, 生物活性小分子, 细胞信号转导和神经科

产品应用

  • Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

相关文献及参考

  • Moret, C., et al.: Neuropharmacology, 24, 1211 (1985),
  • Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989),
  • Spencer, C.M., et al.: Drugs, 56, 405 (1998),

安全信息

GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P310
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word
RTECSGZ1014010
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Hazard Class6.1
UN Number 2811
Storage condition 0-10°C
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 47100 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3089,1994

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3089,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 213 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3089,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1650 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Newborn - sex ratio
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3171,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 28,3197,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 520 mg/kg
SEX/DURATION            : female 17-20 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules

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