D4476 4-(4-(2,3-二氢苯并[b][1,4]二恶英-6-基)-5-(吡啶-2-基)-1H-咪唑-2-基)苯甲酰胺

CAS 301836-43-1 MFCD09037526

化学结构图

301836-43-1
SMILES: NC(=O)C1C=CC(=CC=1)C1NC(=C(N=1)C1=CC2OCCOC=2C=C1)C1C=CC=CN=1

化学属性

Mol. FormulaC23H18N4O3
Mol. Weight398.41

别名和识别编码

Chemical NameD4476
Synonym 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
CAS Number301836-43-1
Chemical Name Translation4-(4-(2,3-二氢苯并[b][1,4]二恶英-6-基)-5-(吡啶-2-基)-1H-咪唑-2-基)苯甲酰胺
PubChem Substance ID329798715
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Casein Kinase (CK), D-DIF, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, D-DIF, GlaxoSmithKline, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

相关文献及参考

  • Bain, J., et al., The selectivity of protein kinase inhibitors: a further update Biochem. J. 408 , 297-315, (2007) 摘要
  • Rena, G., et al. , D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a EMBO Rep. 5 , 60-65 , (2004) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Casein Kinase (CK) - Serine/Threonine Kinase Inhibitors

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