Elacridar N-(4-(2-(6,7-二甲氧基-3,4-二氢异喹啉-2(1H)-基)乙基)苯基)-5-甲氧基-9-氧代-9,10-二氢吖啶-4-甲酰胺

CAS 143664-11-3 MFCD00912604

化学结构图

143664-11-3
SMILES: COc1cc2c(cc1OC)CN(CCc1ccc(NC(=O)c3cccc4c(=O)c5cccc(OC)c5[nH]c34)cc1)CC2

化学属性

Mol. FormulaC34H33N3O5
Mol. Weight564

别名和识别编码

Chemical NameElacridar
CAS Number143664-11-3
Synonym Elacridar GF 120918 GF-120918 GF120918 GF120918 GG918 GW0918 N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide GF120918A GG 918 GG918 GW 0918 N-(4-(2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide elacridar n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10h-acridine-4-carboxamide
MDL NumberMFCD00912604
Chemical Name TranslationN-(4-(2-(6,7-二甲氧基-3,4-二氢异喹啉-2(1H)-基)乙基)苯基)-5-甲氧基-9-氧代-9,10-二氢吖啶-4-甲酰胺
Reaxys-RN7324887
LabNetwork Molecule IDLN00337963
PubChem Substance ID119373
InChIInChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
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分类

  • Pharmaceuticals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Drug Efflux Pumps, E, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, New Products
  • Intermediates & Fine Chemicals,
  • Inhibitors

产品应用

  • A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.

相关文献及参考

  • Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004),
  • Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005),
  • Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),

安全信息

RTECSAR7621300
WGK Germany3
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition <0°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Multi-Drug Resistance - Multi-Drug Resistance and Drug Metabolism
  6. Drug Efflux Pumps - Multi-Drug Resistance
  7. Modulators for MDR/TAP Transporters - Drug Efflux Pumps

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