Heptaplatin 顺式-丙二酸双胺甲基二氧戊环合铂((II)

CAS 146665-77-2 MFCD00931412

化学结构图

146665-77-2
SMILES: CC(C)C1O[C@H](CN)[C@@H](CN)O1.O=C1CC(=O)O[Pt]O1

化学属性

Mol. FormulaC11H20N2O6Pt
Mol. Weight471

别名和识别编码

Chemical NameHeptaplatin
CAS Number146665-77-2
Synonym (SP-4-2)-[(4R,5R)-2-(1-Methylethyl-1,3-dioxolane cis-Malonato((4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane)platinum(II) NSC D644591 SKI 2053R
Chemical Name Translation顺式-丙二酸双胺甲基二氧戊环合铂((II)
MDL NumberMFCD00931412
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A coordination compound for treatment of cervix cancer.

相关文献及参考

  • Jiang, M., et al.: Methods Mol. Biol., 292, 401 (2005),

安全信息

RTECSTP2505900 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1590 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 198 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJTOEA Korean Journal of Toxicology.  (Korean Society of Toxicology, c/o
   College of Medicine, Seoul National University, Seoul, 110, S. Korea)  V.1-
   1985-  Volume(issue)/page/year: 8,205,1993

系列性分类

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