(S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-f]Indolizine-3,6,10(4H)-Trione (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-f]吲哚嗪-3,6,10(4H)-三酮

CAS 110351-94-5 MFCD09833229

化学结构图

110351-94-5
SMILES: CCC1(O)C(=O)OCc2c1cc1n(c2=O)CCC1=O

化学属性

Mol. Weight277.28
Mol. FormulaC14H15NO5

别名和识别编码

Chemical Name(S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-f]Indolizine-3,6,10(4H)-Trione
CAS Number110351-94-5
Alfabeta NameHYDROXYPROPYLDIHYDROPYRANOINDOLIZINETRIONE SHFH447813436104[](())------------,,,,
MDL NumberMFCD17011873
Synonym (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
Chemical Name Translation(S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-f]吲哚嗪-3,6,10(4H)-三酮
LabNetwork Molecule IDLN00337595
PubChem Substance ID10220900
InChIInChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1
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分类

  • Chiral Reagents
  • Heterocycles
  • Intermediates
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate in the synthesis of Irinotecan (I767500) and Camptothecin (C175150) analogs.

相关文献及参考

  • Hsiang, Y., et al.: J. Biol. Chem., 260, 14873 (1985),
  • Bao, Y., et al.: Chin. J. Med. Chem., 18, 263 (2008),
  • Miao, Z., et al.: Bioorg. Med. Chem., 16, 1493 (2008),

安全信息

Warnings IRRITANT
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P305+P351+P338
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

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