4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide 4-甲基-3-((4-(3-吡啶基)-2-嘧啶基)氨基)-N-(5-(4-甲基-1H-咪唑-1-基)-3-(三氟甲基)苯基)苯甲酰胺

CAS 641571-10-0 MFCD09833716

化学结构图

641571-10-0
SMILES: CC1C=CC(=CC=1NC1N=C(C=CN=1)C1C=NC=CC=1)C(=O)NC1C=C(C=C(C=1)C(F)(F)F)N1C=NC(C)=C1

化学属性

Mol. FormulaC28H22F3N7O
Mol. Weight530
Density1.36
Melting Point230-242

别名和识别编码

Chemical Name4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide
CAS Number641571-10-0
Alfabeta NameMETHYLMETHYLIMIDAZOLYLTRIFLUOROMETHYLPHENYLPYRIDINYLPYRIMIDINYLAMINOBENZAMIDE NH4341153432(((((())))))-------------------
MDL NumberMFCD09833716
Synonym 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide
Chemical Name Translation4-甲基-3-((4-(3-吡啶基)-2-嘧啶基)氨基)-N-(5-(4-甲基-1H-咪唑-1-基)-3-(三氟甲基)苯基)苯甲酰胺
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分类

  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Nilotinib (AMN1O7) might be useful in treatment of chronic myelogenous leukemia.

相关文献及参考

  • Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002),
  • Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005),
  • Gleixner, K., et al.: Blood, 107, 752 (2006),

安全信息

Warnings IRRITANT
GHS Symbol
RTECSCV5581770

系列性分类

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