4-(1-hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide 4-(1-羟基-2-甲基丙-2-基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2'-联嘧啶]-4-基)苯磺酰胺
CAS 253688-60-7 MFCD09840701
化学结构图
SMILES: COC1C=CC=CC=1OC1C(NS(=O)(=O)C2=CC=C(C=C2)C(C)(C)CO)=NC(=NC=1OCCO)C1=NC=CC=N1
化学属性
| Mol. Formula | C27H29N5O7S |
|---|---|
| Mol. Weight | 567.61 |
| Melting Point | 128-132 |
别名和识别编码
| Chemical Name | 4-(1-hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide |
|---|---|
| CAS Number | 253688-60-7 |
| Synonym | 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy) |
| Chemical Name Translation | 4-(1-羟基-2-甲基丙-2-基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2'-联嘧啶]-4-基)苯磺酰胺 |
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信息真实价格透明
资金保障
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分类
- Aromatics
- Heterocycles
- Metabolites & Impurities
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- The active metabolite of Bosentan, a mixed endothelin receptor antagonist which is used as a vasodilator.
相关文献及参考
- Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994),
- Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996),
- Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996),
- [1]. Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.
安全信息
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