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分类

• {SNA} Catalysis and Inorganic Chemistry, Chemical Synthesis, Homogeneous Pd Catalysts, Palladium Catalysts, Phosphine Compounds, Phosphine Ligands
• {SNA} Catalysis, Catalysis and Inorganic Chemistry, Chemical Synthesis, Development Quantities for Research, Homogeneous Pd Catalysts, Palladium
• {SNA} Catalysis and Inorganic Chemistry, Chemical Synthesis, Homogeneous Pd Catalysts, Palladium
• {SNA} Catalysis and Inorganic Chemistry, Chemical Synthesis, Homogeneous Pd Catalysts, Palladium, Phosphine Compounds, Phosphine Ligands
• {SNA} ChemDose, Chemical Synthesis, Specialty Synthesis

产品应用

• 主要用于Sonogoshira 偶联等偶联反应；卤代物的羰基化催化剂；卤代烷制醛、羧酸、酰胺等；卤代烷与乙炔反应成碳链增长的炔化合物。

相关文献及参考

• Catalyst for the carbonylation of benzyl halides with CO in an alcohol, in the presence of a base, e.g. 1,8-Bis(dimethyl­amino)­naphthalene, L00313, to give arylacetic esters: J. Org. Chem., 40, 532 (1975). Similarly, allylic chlorides are carbonylated to give predominantly ß-unsaturated acids at atmospheric pressure: Chem. Lett., 957 (1988), and bromo alkanols give lactones: J. Am. Chem. Soc., 102, 4193 (1980):
• An improved procedure uses triethylamine in THF with catalytic amounts of CuI and the complex, avoiding the need for excess of the acetylene, and gives good yields under mild conditions, even with unreactive aryl bromides: J. Org. Chem., 63, 8551 (1998).
• For use as catalyst in the Stille coupling of arylstannanes, see Tri-n-butyl­tin chloride, A10746. For examples of the Stille coupling of arylstannanes with aryl triflates to give unsymmetrical biaryls, see: Org. Synth. Coll., 9, 553 (1998). For reviews, see: Adv. Met.-Org. Chem., 5, 1 (1996); Org. React, 50, 1 (1997).
• Catalyzes the exclusively cis-addition of Tri-n-butyl­tin hydride, A13298, to alkynes at room temperature, to give vinylstannanes in good yield: J. Org. Chem., 55, 1857 (1990):
• In combination with acetic anhydride and triphenylphosphine, catalyzes
• Terminal alkynes give a mixture of regioisomers.
• In combination with acetic anhydride and triphenylphosphine, catalyzes the selective conversion of carboxylic acids to 1-alkenes of one less carbon atom: J. Org. Chem., 58, 29 (1993).
• In combination with CuI and an amine, catalyzes the Sonogashira coupling of terminal alkynes with aryl, vinyl, styryl and 2-pyridyl halides: Tetrahedron Lett., 4467
• Catalyst for a wide range of coupling reactions:
• Also catalyzes the low-pressure carbonylative cross-coupling of arylboronic acids with iodoarenes to give unsymmetrical biaryl ketones: Tetrahedron Lett., 34, 7595 (1993); J. Org. Chem., 63, 4726 (1998).

安全信息

其他信息

• 黄色。不溶于水。 溶于甲苯、苯，微溶于丙酮、氯仿。