N-(2-Hydroxyethyl)piperazine N-(2-羟乙基)哌嗪

CAS 103-76-4 MFCD00005970

化学结构图

103-76-4
SMILES: OCCN1CCNCC1

化学属性

Mol. FormulaC6H14N2O
Mol. Weight130.19
Refractive index1.5060 to 1.5080
Boiling Point246°C at 760 mmHg
Density1.061
Flash Point135°C
TSCAYes
Melting Point-38.5 °C
SolubilityMISCIBLE
pH:A

别名和识别编码

Chemical NameN-(2-Hydroxyethyl)piperazine
CAS Number103-76-4
Alfabeta NameHYDROXYETHYLPIPERAZINE N2()--
MDL NumberMFCD00005970
Synonym 1-(2-Hydroxyethyl)piperazine {LY} 1-(2-Hydroxyethyl)piperazine {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-(2-Hydroxyethyl)piperazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID87574943
EC Number203-142-3
Beilstein Registry Number104361
Reaxys-RN104361
Chemical Name TranslationN-(2-羟乙基)哌嗪
Wiswesser Line NotationT6M DNTJ D2Q
LabNetwork Molecule IDLN00174249
InChIInChI=1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
Canonical SMILESOCCN1CCNCC1
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分类

  • {SNA} Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
  • Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines

产品应用

  • 用于有机合成。

相关文献及参考

  • Franc, Z. et al.: Ces.-Slov. Farm., 32, 326 (1983);
  • Beilstein:20(3/4)387

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany1
Hazard Codes Xi
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTL6825000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
Signal word Warning
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 1/6/1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4920 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3720 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(5),67,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 5

Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitr

其他信息

  • MOL 文件:103-76-4.mol
  • Acros Organics:N-2-羟乙基哌嗪 N-(2-Hydroxyethyl)piperazine, 98.50%(103-76-4)
  • 海关编码:29335995
  • 用途一:是生产三乙烯二胺、表面活性剂、医药、农药的重要中间体,可用于合成精神病药氟奋乃静等
  • 图谱信息:1-(2-羟乙基)哌嗪(103-76-4)核磁图( 13 CNMR) 1-(2-羟乙基)哌嗪(103-76-4)红外图谱(IR2) 1-(2-羟乙基)哌嗪(103-76-4)红外图谱(IR1) 1-(2-羟乙基)哌嗪(103-76-4)核磁图( 1 HNMR) 1-(2-羟乙基)哌嗪(103-76-4)Raman光谱 1-(2-羟乙基)哌嗪(103-76-4)质谱(MS)
  • 上游原料:哌嗪(六水)
  • 方法一:由六水哌嗪与环氧乙烷反应而得。将六水哌嗪溶解于水,搅拌冷却至15-20℃,通入环氧乙烷。通毕,于30-35℃,搅拌反应2h,加热蒸出原加水量的90%。冷至15℃以下,过滤。滤液进行减压蒸馏,收集145-155℃(5.33kPa)馏分,得N-(2-羟乙基)哌嗪。
  • 1-(2-羟乙基)哌嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0812 1-哌嗪乙醇 1-Piperazineethanol 25G 229元 2014/06/02 P0812 1-哌嗪乙醇 1-Piperazineethanol 500G 1150元 2010/06/21 121195000 1-(2-羟乙基)哌嗪 N-(2-Hydroxyethyl)piperazine 98.5% 500 GR 2137元
  • 下游产品:马尼地平 --> 二马来酸乙酰奋乃静 --> 1-羟乙基-4-甲基哌嗪
  • 用途二:用于有机合成。
  • Hazard Note:Irritant
  • TCI Shanghai:1-哌嗪乙醇 1-Piperazineethanol,>;99.0%(GC)(103-76-4)
  • Sigma Aldrich:103-76-4(sigmaaldrich)
  • Alfa Aesar:N-(2-羟乙基)哌嗪,98+% 1-(2-Hydroxyethyl)piperazine, 98+%(103-76-4)
  • MSDS 信息:1-Piperazineethanol(103-76-4).msds

系列性分类


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