2-Chloropyridine 2-氯吡啶

CAS 109-09-1 MFCD00006228

化学结构图

109-09-1
SMILES: Clc1ccccn1

化学属性

Mol. FormulaC5H4ClN
Mol. Weight113.55
Density1.2
Refractive index1.5320
Flash Point65°(149°F)
TSCAYes
Boiling Point170°C
Melting Point-46°C
Vapor Pressure1.7 mmHg ( 20 °C)
Solubility溶于芳烃、卤代烃。
pH:A

别名和识别编码

Chemical Name2-Chloropyridine
MDL NumberMFCD00006228
EC Number203-646-3
CAS Number109-09-1
Beilstein Registry Number105788
PubChem Substance ID7977
Synonym 2-Chloropyridine ,99% 萘脲 邻氯吡啶 α-chloropyridine 2-Pyridinyl chloride Pyridine, 2-chloro- alpha-Chloropyridine 2-CHLOROPYRIDINE 2-氯吡啶99﹪ o-Chloropyridine ALPHA-CHLOROPYRIDINE 2-氯吡啶 2CLPY 2-chloro-pyridin
Chemical Name Translation2-氯吡啶
Wiswesser Line NotationT6NJ BG
LabNetwork Molecule IDLN00198394
InChIInChI=1S/C5H4ClN/c6-5-3-1-2-4-7-5/h1-4H
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分类

  • {SNA} Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines

产品应用

  • 医药、杀菌剂等，有机合成的中间体。

相关文献及参考

  • Reaction with the unimetal suberbase complex formed from 2 mol of n-BuLi and I mol of 2-(Dimethyl­amino)­ethanol, B23616, in hexane, gives products resulting from apparent metallation at the 6-position, providing useful access to 6-functionalized 2-chloropyridines: Org. Lett., 2, 803 (2000). See also 2-Methoxypyridine, A13675, for a similar effect.
  • Beilstein: 20,V,5,402

安全信息

RTECSUS5950000
Packing GroupII
UN Number UN2822 UN 2822 6.1/PG 2
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H301+H331
  • H310 Fatal in contact with skin 皮肤接触致命
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Signal word Danger
Hazard Codes T
Hazard Class6.1
Restrict {} 剧毒化学品 危险品
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - fatty liver degeneration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    195

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 ppm/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - fatty liver degeneration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1980 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 400 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 176,185,1987

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1920 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 4000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1920 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

其他信息

  • 2-氯吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 110015000 2-氯吡啶 2-Chloropyridine 99% 500 ML 973元 2010/06/21 110010025 2-氯吡啶 2-Chloropyridine 99% 2.5 LT 3865元 2010/06/21 110011000 2-氯吡啶 2-Chloropyridine 99% 100 ML 255元
  • 用途二:防霉剂如吡硫霉净的中间体。
  • 用途三:医药、杀菌剂等，有机合成的中间体。
  • Sigma Aldrich:109-09-1(sigmaaldrich)
  • Hazard Note:Toxic
  • 能随水蒸气挥发。溶解度: 27 g/l 水(20°C) ，>50 g/100ml 乙醇， 溶于醚。
  • 类别:有毒物品
  • MSDS 信息:2-氯吡啶(109-09-1).msds
  • 灭火剂:干粉, 泡沫, 砂土
  • 急性毒性:吸入-大鼠 LCL0: 100 PPM/4小时; 口服-小鼠 LD50: 110 毫克/公斤
  • 蒸气压:1.7 mm Hg ( 20 °C)
  • 上游原料:吡啶 --> 2-氨基吡啶
  • 用途一:用于医药、杀虫剂、有机合成
  • MOL 文件:109-09-1.mol
  • 储运特性:库房通风低温干燥; 与氧化剂, 食品分开储运
  • 下游产品:2-吗啉代吡啶-3-醛 --> 2-氯-3-吡啶甲醛 --> 二苯基-2-吡啶膦 --> 2-氯-4-硝基吡啶 N-氧化物 --> 4-吡啶-2-异恶唑-5-胺 --> 2-氯-6-三氟甲基烟酸 --> 氯吡脲 --> 5-氨基甲基-2-氯吡啶 --> N-(4-硝基吡啶-2-基)乙酰胺 --> 2-氨基-4-硝基吡啶 --> 2-乙酰氨基-4-硝基吡啶-N-氧化物 --> 2-氯吡啶-N-氧化物 --> 2-氨基-4-硝基吡啶-N-氧化物 --> 2-氯-4-氨基吡啶盐酸盐 --> 吡丙醚 --> 2-氯-4-硝基吡啶 --> 2-氯-3-(2-硝基苯甲酰氨基)吡啶 --> 双(1-羟基-1H-吡啶-2-硫代硫酸-O,S)铜
  • 可燃性危险特性:可燃; 燃烧产生有毒氧化氮, 氯化物气体
  • 检测方法:HPLC,NMR
  • 图谱信息:2-氯吡啶(109-09-1)红外图谱(IR1) 2-氯吡啶(109-09-1)核磁图( 13 CNMR) 2-氯吡啶(109-09-1)核磁图( 1 HNMR) 2-氯吡啶(109-09-1)质谱(MS)
  • Acros Organics:2-氯吡啶 2-Chloropyridine, 99%(109-09-1)
  • 毒性分级:高毒
  • Alfa Aesar:2-氯吡啶,99% 2-Chloropyridine, 99%(109-09-1)
  • 外观性质:无色液体。
  • 海关编码:29333999
  • 方法一:用2-氨基吡啶经桑德曼尔反应制得。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyridines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyridazines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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