• 原料直供
• 试剂商城
• 直接询价

分类

• {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; ether; 1fragment
• {SNA} Building Blocks,
• {SNA} Additional Standards, Alpha Sort, Analytical Standards, Chemical Class, Chromatography, Environmental Standards, Food and Cosmetic Component Standards, Heterocyclics, M, M-P, Mixed,

产品应用

• 吗啉与无机酸反应生成盐，与有机酸反应生成盐或酰胺。可进行烷基化反应，还可以与环氧乙烷、酮反应或进行Willgerodt反应。

相关文献及参考

• In the Kindler modification of the Willgerodt reaction, aryl ketones are converted to ω-arylalkanoic acids by reaction with sulfur and an amine, usually morpholine: Org. Synth. Coll., 9, 99 (1998); reviews: Org. React., 3, 83 (1946); Synthesis, 358 (1975).
• Reagent for the cleavage of Fmoc protecting groups in peptide synthesis (see 9-Fluorenyl­methyl­ chloroformate, A11683): J. Am. Chem. Soc., 92, 5748 (1970); J. Org. Chem., 37, 3404 (1972). See Appendix 6 for peptide reagents.
• Short: II/19b
• Chlorination with hypochlorite gives N-chloromorpholine, a useful reagent in strongly acid media for the selective chlorination of activated aromatics: Org. Synth. Coll., 8, 167 (1993), and references therein.
• Merck:14,6277
• Merck:14,6277 Beilstein:27,5
• Lithium morpholide adds to aromatic aldehydes at low temperature, a useful means for the protection of the aldehyde group in lithiations: Tetrahedron Lett., 25, 4213 (1981); J. Org. Chem., 48, 2356 (1983).
• Short: II/14a

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2560 mg/kg/Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - bronchiogenic carcinoma
   Liver - tumors
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 44(8),15,1979

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 12000 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,90,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 458 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4576951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 413 mg/kg
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1055,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1220 mg/kg
TOXIC EFFECTS :
   Details of toxic

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 125 mg/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 uL/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,390,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 160 mg/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 gm/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

其他信息

• 外观性质:无色油状液体，有氨味。
• 用途六:1,4-氧氮六环（110-91-8）主要应用于生产橡胶促进剂、合成病毒灵、布烙芬、咳必定等多种药物，在油漆、农药、增白剂、溶剂等方面也有广泛用途。还可用于制造N-甲基吗啉、N-乙基吗啉等多种中间体。
• 刺激数据:皮肤-兔子 995 毫克/24小时 重度; 眼睛-兔子 2 毫克 重度
• TCI Shanghai:吗啉 Morpholine,>;99.0%(GC)(110-91-8)
• 上游原料:氢氧化钠 --> 硫酸 --> 氨 --> 1,4-二氧六环 --> 氢 --> 4-氯苯甲醛 --> 二乙醇胺 --> 二乙二醇
• 具有吸湿性和特殊的胺味，能以任何比例与水互溶，易溶于芳烃、醇、酮类、醚类和有机溶剂中，微溶于矿物油和脂肪族烃中，有轻微毒性。能随水蒸气挥发。
• 方法二:由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内，在60℃以下滴加硫酸，加毕，升温于185-195℃，保温30min。冷至60℃以下，滴加氢氧化钠液至pH=11，冷却，过滤，滤液精馏，收集130℃以下馏分，精吗啉含量可达99.5%以上。该法原料易得，目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。
• 图谱信息:1,4-氧氮六环(110-91-8)Raman光谱 1,4-氧氮六环(110-91-8)红外图谱(IR1) 1,4-氧氮六环(110-91-8)核磁图( 1 HNMR) 1,4-氧氮六环(110-91-8)核磁图( 13 CNMR) 1,4-氧氮六环(110-91-8)质谱(MS)
• 参考质量标准:FCC，1996 含量 ≥99.0% 馏程 126.0～130.0℃ 重金属(以Pb计) ≤1mg/kg 折射率(n D 20 ) 1.454～1.455 相对密度(d 25 25 ) 0.994～0.997
• 灭火剂:干粉, 二氧化碳, 泡沫, 雾状水
• 含量分析:取0.1%溴甲酚绿的甲醇液4份，0.1%甲基红钠盐的水溶液1份，混合，作为混合指示剂。 一250m1烧瓶中盛水50m1，加上述混合指示剂0.4ml，逐滴加入0.1moI/L盐酸，中和至绿色。准确称取试样1.4～1.6g，加入该烧瓶，混匀。用0.5mol/L盐酸滴定至绿色。每ml，0.5mol/L盐酸相当于C 4 H 9 NO 43.56mg。
• 用途一:促进剂NOBS的主要原料,有作分析试剂及树脂、蜡类、虫胶等的溶剂 ,用于生产硫酸钠.水玻璃和群青等。还用于制造玻璃.造纸.洗涤剂.肥皂.染料.合成纤维.制革.医药和陶瓷等行业。分析试剂，如氮的测定，脱水剂。
• 产品特性:吗啉又称为1,4-氧氮杂环己烷，常温下是一种无色油状液体，能与水、丙酮、醚、苯、醇、乙二醇和油类混溶，有吸湿性和氨味，可随水蒸汽挥发。 吗啉含有仲胺基团，具有仲胺基团的所有典型反应特征。与无机酸反应生成盐，与有机酸反应生成盐或酰胺，可进行烷基化反应，还可以与环氧乙烷、酮反应或进行Willgerodt反应。由于吗啉所具有的独特的化学性质，使其成为当前具有重要商业用途的精细石油化工产品之一,可用于制备NOBS、DTOS和MDS等橡胶硫化促进剂、防锈剂、防腐蚀剂、清洁剂、除垢剂、止痛药、局部麻醉剂、镇静剂、呼吸系统与血管兴奋剂、表面活化剂、光学漂白剂、水果保鲜剂、纺织印染助剂等，在橡胶、医药、农药、染料、涂料等行业有着广泛的用途，医药方面用于生产吗啉胍、病毒灵、布洛芬、咳必定、萘普生、二氯苯胺、苯乙酸钠等多种重要药物。 吗啉的生产方法主要有DEA法(二乙醇胺法)和DEG法(二甘
• Sigma Aldrich:110-91-8(sigmaaldrich)
• 毒性:LD 50 1050mg/kg(大鼠，经口)。
• 类别:易燃液体
• 毒性防护:蒸气刺激皮肤及眼粘膜，引起呼吸困难，具有全身毒性作用，可引起肝，肾变性及坏死性病变。人体在43mg/L浓度下，作用1分钟，对鼻粘膜产生强烈
• 用途四:吗啉是杀菌剂烯酰吗啉和氟吗啉及有机磷杀虫剂茂硫磷的中间体。
• 下游
• 职业标准:TLV-TWA 70