1-Methylpyrrolidine 1-甲基吡咯烷

CAS 120-94-5 MFCD00003173

化学结构图

120-94-5
SMILES: CN1CCCC1

化学属性

Mol. FormulaC5H11N
Mol. Weight85
Density0.819
Refractive index1.4210 to 1.4250
Flash Point3°C(lit.)
TSCAYes
Boiling Point80-81
Melting Point-90°
SolubilityFULLY MISCIBLE
Appearance 无色透明易挥发液体。凝固点-90℃，沸点79.5～80.5℃，相对密度0.819，折光率1.4240，闪点-21℃。易溶于水，溶于醇、醚等有机溶剂。
Stability对空气敏感

别名和识别编码

Chemical Name1-Methylpyrrolidine
CAS Number120-94-5
Synonym 1-METHYLPYRROLIDINE 1-Methylpyrrolidine 1-methyl N-methylpyrrolidine N-甲基吡咯烷 N-甲基四氢吡咯 PYRROLIDINE, N-METHYL Pyrrolidine, 1-methyl- methylpyrrolidine(non-specificname) {} {} {} {} {} {} {uni_hamburg}
MDL NumberMFCD00003173
EC Number204-438-5
Beilstein Registry Number102445
PubChem Substance ID87572474
Chemical Name Translation1-甲基吡咯烷
Reaxys-RN102445
Wiswesser Line NotationT5NTJ A1
LabNetwork Molecule IDLN00222288
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 5ring; 1fragment
  • {SNA} Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Pyrrolidines
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Aliphatics

产品应用

  • 医药中间体。

相关文献及参考

  • Short: II/19c
  • Beilstein:20,4
  • Short: II/19b
  • Prasanna, S.J. et al.: J. Chrom. Sci., 48, 830 (2010); Adam, T. et al.: Anal. Chim. Acta, 657, 36 (2010);

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S29 Do not empty into drains 不要排入下水道；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSUY1420500
Packing GroupII
UN Number 2924
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3 F,C
Storage condition 密封保存 Flammables area 充氩保存
Hazard Class3/8 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,82,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,82,1946

其他信息

  • 易溶于水，溶于醇、醚等有机溶剂。
  • Sigma Aldrich:120-94-5(sigmaaldrich)
  • 用途一:用作医药中间体
  • 图谱信息:1-甲基吡咯烷(120-94-5)质谱(MS) 1-甲基吡咯烷(120-94-5)核磁图( 13 CNMR) 1-甲基吡咯烷(120-94-5)红外图谱(IR1)
  • MOL 文件:120-94-5.mol
  • Alfa Aesar:1-甲基吡咯烷,98% 1-Methylpyrrolidine, 98%(120-94-5)
  • 下游产品:盐酸氮卓斯汀 --> 1-正丁基-1-甲基吡咯烷二(三氟甲基磺酰)酰亚胺,98% --> N-甲基-2-吡咯羧酸
  • TCI Shanghai:1-甲基吡咯烷 1-Methylpyrrolidine,>;98.0%(GC)(T)(120-94-5)
  • 1-甲基吡咯烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K6911001 1-甲基吡咯烷 100ml 260元 2011/04/16 M0415 1-甲基吡咯烷 1-Methylpyrrolidine 500ML 972元 2011/04/16 M0415 1-甲基吡咯烷 1-Methylpyrrolidine 25ML 209元
  • MSDS 信息:1-Methylpyrrolidine(120-94-5).msds
  • 检测方法:GC
  • Acros Organics:N-甲基吡咯烷 1-Methylpyrrolidine, 98%(120-94-5)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrroles 吡咯
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrrolidines 吡咯烷
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrrolidines 吡咯烷
  5. C4 to C10 - Pyrrolidines