Formamidine acetate 醋酸甲脒

CAS 3473-63-0 MFCD00012866

化学结构图

3473-63-0
SMILES: CC(=O)O.N=CN

化学属性

Mol. FormulaC3H8N2O2
Mol. Weight104.11
Melting Point158-161°C
Density1.124
TSCAYes
Solubility832 G/L (21 ºC)
Stability易吸潮
Appearance 白色结晶。熔点162-164℃。

别名和识别编码

Chemical NameFormamidine acetate
Synonym Formimidamide (acetate) {LY} Formimidamide (acetate) {} {LY} Formimidamide (acetate) {} {} {LY} Formimidamide (acetate) {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formimidamide (acetate)
CAS Number3473-63-0
PubChem Substance ID160693
EC Number222-442-5
Beilstein Registry Number3563488
MDL NumberMFCD00012866
Reaxys-RN3563488
Chemical Name Translation醋酸甲脒
InChIKeyXPOLVIIHTDKJRY-UHFFFAOYSA-N
LabNetwork Molecule IDLN00168830
InChIInChI=1S/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)
Canonical SMILESO=C(C)O.N=CN
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分类

  • Building Blocks, Chemical Synthesis, Imines/Amidines, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; carboxylate; 2fragments; ionic
  • {SNA} Building Blocks, Chemical Synthesis, Imines/Amidines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 用于合成4-羟基-5-氟嘧啶。

相关文献及参考

  • Short: III/20a
  • Short: EINECS
  • More convenient source of formamidine than the corresponding chloride in that it is non-hygroscopic and, being the salt of a weaker acid, can often be used in synthesis without the need to liberate the free base.
  • Widely used in heterocyclic syntheses, for example of pyrimidine and imidazole derivatives.

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xi
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P333+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S37 Wear suitable gloves 戴适当手套;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic Store at room temperature {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {L

其他信息

  • TCI Shanghai:乙酸甲脒 Formamidine Acetate,>;98.0%(T)(3473-63-0)
  • Acros Organics:乙酸甲脒 Formamidine acetate, 99%(3473-63-0)
  • Alfa Aesar:乙酸甲脒,99% Formamidine acetate, 99%(3473-63-0)
  • F:3-9-21
  • 海关编码:29252000
  • Sigma Aldrich:3473-63-0(sigmaaldrich)
  • MSDS 信息:Methanimidamide monoacetate(3473-63-0).msds
  • 方法一:由原甲酸三乙酯和冰醋酸通氨缩合而得。将原甲酸三乙酯加入冰醋酸中加热,通氨反应1.5h,析出白色结晶,再继续通氨半小时。反应物先进行常压蒸馏,后经减压减压蒸馏将醇蒸尽。冷至25℃,用无水乙醇洗涤、过滤、干燥,得乙酸甲脒。
  • 敏感性:Hygroscopic
  • 醋酸甲脒价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0154 乙酸甲脒 Formamidine Acetate 250G 934元 2014/06/02 F0154 乙酸甲脒 Formamidine Acetate 25G 215元 2010/06/21 119711000 醋酸甲脒 Formamidine acetate 99% 100 GR 471元
  • 下游产品:4-羟甲基咪唑盐酸盐 --> 4,6-二甲基嘧啶-5-甲酸 --> 5-硝基-4-羟基嘧啶 --> 4-羟基-6-三氟甲基嘧啶 --> 5-甲基-4,6-二羟基嘧啶 --> 4-氨基嘧啶-5-羧酰胺 --> 5-溴-4-氯-7H-吡咯并[2,3-d]嘧啶 --> 4-氨基-6-甲基嘧啶-5-甲腈 --> 4-氨基嘧啶-5-甲腈 --> 4-羟基-5-氟嘧啶
  • 用途一:用于合成4-羟基-5-氟嘧啶。
  • MOL 文件:3473-63-0.mol
  • 水中溶解度: 832 g/L (21°C)

系列性分类


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