2-Chlorophenol 2-氯苯酚

CAS 95-57-8 MFCD00002159

化学结构图

95-57-8
SMILES: Oc1ccccc1Cl

化学属性

Mol. FormulaC6H5ClO
Mol. Weight128.56
Refractive index1.5570 to 1.5610
Boiling Point175-176
Density1.241
Melting Point8
Flash Point63.89°C
TSCAYes
Solubility28.5 G/L (20 ºC)
Stability对光敏感
pH-:A
Danger-Level-
Redox-

别名和识别编码

Chemical Name2-Chlorophenol
CAS Number95-57-8
PubChem Substance ID7245
EC Number202-433-2
Beilstein Registry Number1905114
MDL NumberMFCD00002159
Reaxys-RN1905114
Merck Number2154
Synonym 2-Chlorophenol {LY} 2-Chlorophenol 2-Chlorphenol 2-chloro-1-hydroxybenzene 2-chloro-pheno 2-chloro-phenol 2-chlorophenol(o-chlorophenol) 2-氯-1-羟基苯 2-氯苯酚,98+% 2-氯苯酚;邻氯苯酚;邻氯苯酚溶液;2-氯-1-羟基苯;2-羟基氯苯;邻羟基氯苯 2-氯酚 2-羟基氯苯 o-Chlorophenic acid o-Chlorphenol CHLOROPHENOL(O-) Phenol, o-chloro- Phenol, o-chloro- RCRA waste number U048 Rcra waste number U048 o-Chlorophenol o-chloro-pheno o-chlorophenicacid phenol, 2-chloro- pine-odisinfectant rcrawastenumberu048 {} {LY} 2-Chlorophenol {} {} {LY} 2-Chlorophenol {} {} {} {LY} 2-Chlorophenol {} {} {} {} {LY} 2-Chlorophenol {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {LY} 2-Chlorophenol {} {}
Chemical Name Translation2-氯苯酚
Wiswesser Line NotationQR BG
LabNetwork Molecule IDLN00200298
InChIInChI=1S/C6H5ClO/c7-5-3-1-2-4-6(5)8/h1-4,8H
Canonical SMILESOC1=CC=CC=C1Cl
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分类

  • {SA} Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, C, CH, Chromatography, Environmental Standards,

产品应用

  • 有机合成,染料制造,杀菌剂。

相关文献及参考

  • Short: II/25D
  • Merck: 14,2154 Beilstein:6,183
  • Merck: 14,2154
  • Short: II/14a
  • Has been used as a reagent for the protection of OH-groups in oligonucleotide synthesis. A study of various cleavage methods showed that the tetramethylguanidine salts of either 4-nitrobenzaldoxime or pyridine-2-carboxaldoxime gave the best results: Tetrahedron Lett., 2727 (1978).

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302+H312+H332
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 6.1 Xn;N
RTECSSK2625000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338+P310
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
UN Number 2021 2021/2905 UN 2021 6.1/PG 3 UN2021
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R51/53
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4800 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   19,413,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,20,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 2,76,1943

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,868,1975

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1580 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - pulmonary emboli
   Liver - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Sci

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 800 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 182,135,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4550 mg/kg
SEX/DURATION            : female 70 day(s) pre-mating
                          female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 46,137,1982

Restrict -

其他信息

  • 上游原料:次氯酸钠 --> 2,4-二氯酚
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-
  • 2-氯苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80034828 2-氯苯酚 500ml 47.3元 2010/06/21 180995000 2-氯苯酚 2-Chlorophenol 98+% 500 GR 406元 2010/06/21 180990025 2-氯苯酚 2-Chlorophenol 98+% 2.5 KG 1493元
  • 图谱信息:2-氯苯酚(95-57-8)Raman光谱 2-氯苯酚(95-57-8)核磁图( 13 CNMR) 2-氯苯酚(95-57-8)质谱(MS) 2-氯苯酚(95-57-8)红外图谱(IR1) 2-氯苯酚(95-57-8)核磁图( 1 HNMR)
  • 方法二:(1)由苯酚钠经氯化、酸化而得。搅拌苯酚钠、水及冰的混合物,于20℃以下慢慢加次氯酸钠溶液,控制温度在20℃以下,室温放置过夜,搅拌下加浓盐酸酸化至pH为2,水洗一次,再用5%碳酸钠溶液洗至洗液pH为4-5,冷却后,分出油层,进行常压分馏,再经减压蒸馏而得成品。(2)由苯酚用氯气氯化。在搅拌下将熔融的苯酚加入苯中,在26±2℃通入氯气,至氯
  • {Chemi
  • 有不愉快的刺激性气味。易溶于醇、醚、氯仿、甘油、挥发油类和苛性碱溶液,微溶于水。低毒,半数致死量(大鼠,经口)670mg/kg。有腐蚀性。
  • 方法一:邻氯苯酚是生产对氯苯酚的联产品,用苯酚氯化得到的
  • {Chemicalboo
  • 方法一:邻氯苯酚是生产对氯苯酚的联产品,用苯酚氯化得到的是邻位和对位的氯代苯酚,经分离可以得到
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-氯苯酚 --> 呋喃酚 --> 丙溴磷 --> 2,6-二氯苯酚 --> 3-氯苯酚 --> {2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧]苯基}(5,6-二氢-1,4,2-二噁嗪-3-基)甲酮O-甲基肟 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 4
  • {Che
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-氯苯酚 --> 呋喃酚 --> 丙溴磷 --> 2,6-二氯苯酚 --> 3-氯苯酚 --> {2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧]苯基}(5,6-二氢-1,4,2-二噁嗪-3-基)甲酮O-甲基肟 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 4-溴-2-氯苯酚 --> 4-溴-2,6-二氯酚 --> 氯
  • 类别:农药
  • 方法二:(1)由苯酚钠经氯化、酸化而得。搅拌
  • F:9
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
  • 酚类单一化合物标准液
  • TCI Shanghai:2-氯苯酚 2-Chlorophenol,>;98.0%(GC)(95-57-8)
  • 用途五:有机合成,染料制造,杀菌剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
  • 可燃性危险特性:明火可燃; 高热放出有毒氯化物气体
  • Sigma Aldrich:95-57-8(sigmaaldrich)
  • 用途三:用于有机合成。邻氯酚经光气化得到氯甲酸邻氯苯酯,是氨基甲酸酯类杀虫剂害扑威的中间体。
  • 毒性分级:高毒
  • {Chemic
  • 用途二:邻氯苯酚是杀虫剂丙溴磷的中间体。
  • 用途一:用于医药、农药和染料及其他有机合成原料
  • Alfa Aesar:2-氯苯酚,99% 2-Chlorophenol, 99%(95-57-8)
  • 急性毒性:口服- 大鼠 LD50: 670 毫克/ 公斤; 口服- 小鼠 LD50: 345 毫克/ 公斤
  • 用途四:有机合成,染料制造,杀菌剂。

系列性分类