1-Bromo-2-fluorobenzene 邻氟溴苯

CAS 1072-85-1 MFCD00000282

化学结构图

1072-85-1
SMILES: Fc1ccccc1Br

化学属性

Mol. FormulaC6H4BrF
Mol. Weight175.00
Boiling Point78-82 °C at 50 mmHg
TSCAT
Density1.601
Refractive index1.5330 to 1.5350
Flash Point50.2°C
Melting Point-8 °C
Solubility不溶
Appearance 淡黄色液体。沸点155℃-157℃，闪点43℃，折光率1.5340，比重1.601。

别名和识别编码

Chemical Name1-Bromo-2-fluorobenzene
CAS Number1072-85-1
Alfabeta NameBROMOFLUOROBENZENE 12---
MDL NumberMFCD00000282
Synonym 1-Bromo-2-fluorobenzene {LY} 1-Bromo-2-fluorobenzene {} {LY} 1-Bromo-2-fluorobenzene {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Bromo-2-fluorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number214-018-3
Beilstein Registry Number1071819
PubChem Substance ID61259
Reaxys-RN1071819
Chemical Name Translation邻氟溴苯
InChIKeyIPWBFGUBXWMIPR-UHFFFAOYSA-N
Wiswesser Line NotationFR BE
LabNetwork Molecule IDLN00115991
InChIInChI=1S/C6H4BrF/c7-5-3-1-2-4-6(5)8/h1-4H
Canonical SMILESFC1=CC=CC=C1Br
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分类

  • {SNA} Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Hydrocarbons, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 医药、农药、液晶材料中间体。

相关文献及参考

  • On treatment with Mg: J. Org. Chem., 49, 4518 (1984), or n-BuLi: Tetrahedron, 48, 4379 (1992), benzyne is generated, which undergoes [4+2] cycloadditions with furans or pyrroles.
  • Short: III/35D2
  • Short: III/38B
  • Whereas n-BuLi effects bromine-metal exchange, lithiation with LDA at -75o results in deprotonation ortho to F; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 36, 881 (1995). Improved yields are obtained by the use of lithium 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).
  • Beilstein: 5,IV,678

安全信息

Warnings IRRITANT, FLAMMABLE
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R10 Flammable 易燃
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P303+P361+P353
  • P305+P351+P338
  • P332+P313
  • P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSDA1050000
Packing GroupIII
UN Number 1993
Hazard Codes 3 Xn
Hazard Class3
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • MSDS 信息:1-Bromo-2-fluorobenzene(1072-85-1).msds
  • TCI Shanghai:1-氟-2-溴苯 2-Bromofluorobenzene,>;99.0%(GC)(1072-85-1)
  • MOL 文件:1072-85-1.mol
  • 用途一:用作医药、农药中间体
  • TSCA:T
  • 下游产品:1,4-环氧-1,4-二氢萘
  • Alfa Aesar:1-溴-2-氟苯,98% 1-Bromo-2-fluorobenzene, 99%(1072-85-1)
  • 图谱信息:邻溴氟苯(1072-85-1)质谱(MS) 邻溴氟苯(1072-85-1)红外图谱(IR1) 邻溴氟苯(1072-85-1)核磁图( 13 CNMR) 邻溴氟苯(1072-85-1)核磁图( 1 HNMR)
  • 海关编码:29036990
  • 邻溴氟苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010066 邻氟溴苯 100g 880元 2011/04/16 B0883 2-溴氟苯 2-Bromofluorobenzene 500G 4900元 2011/04/16 B0883 2-溴氟苯 2-Bromofluorobenzene 25G 460元
  • Acros Organics:2-Bromofluorobenzene, 99%(1072-85-1)
  • Hazard Note:Flammable/Irritant
  • Sigma Aldrich:1072-85-1(sigmaaldrich)
  • 用途二:医药、农药、液晶材料中间体。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Fluorinated Building Blocks 氟化物砌块
  4. Organic Fluorinated Building Blocks - Fluorinated Building Blocks
  5. Other Fluorinated Organic Building Blocks - Organic Fluorinated Building Blocks
  6. Aryl Fluorinated Building Blocks 芳基氟化物
  7. C6 - Aryl Fluorinated Building Blocks
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  6. C6 - Aryl
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  6. C6 - Aryl
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳香卤代烃
  6. C13 to C37+