4-Bromofluorobenzene 对氟溴苯

CAS 460-00-4 MFCD00000342

化学结构图

460-00-4
SMILES: Fc1ccc(Br)cc1

化学属性

Mol. FormulaC6H4BrF
Mol. Weight175
Refractive index1.5260 to 1.5290
Boiling Point150
Density1.593
Melting Point-16
Flash Point56°C(lit.)
TSCAYes
Appearance 1.5270，相对密度 1.593，不溶于水，溶于苯、甲苯、醚等有机溶剂。 1-溴-4-氟苯是无色液体，m.p.-16℃，b.p.150℃，n 20

别名和识别编码

Chemical Name4-Bromofluorobenzene
CAS Number460-00-4
Alfabeta NameBROMOFLUOROBENZENE 14---
MDL NumberMFCD00000342
PubChem Substance ID9993
EC Number207-300-2
Beilstein Registry Number774102
Reaxys-RN774102
Synonym 1-Bromo-4-fluorobenzene 1-Bromo-4-fluorobenzene; p-Bromofluorobenzene 1-Fluoro-4-bromobenzene 1-bromo-4-fluoro-benzen 1-氟-4-溴苯 1-溴-4-氟苯 4-Bromo-1-fluorobenzene 4-Bromofluorobenzene 4-FLUOROBROMOBENZENE 4-Fluorobromobenzene 4-Fluorophenyl bromide 4-bromofluorobenzene 4-fluorophenylbromide p-Fluorbrombenzol Benzene, 1-bromo-4-fluoro- Benzene,1-bromo-4-fluoro- P-BROMOFLUOROBENZENE nsc10268 p-fluorophenylbromide 对氟溴苯;4-溴氟苯;1-溴-4-氟苯
Chemical Name Translation对氟溴苯
InChIKeyAITNMTXHTIIIBB-UHFFFAOYSA-N
LabNetwork Molecule IDLN00176996
InChIInChI=1S/C6H4BrF/c7-5-1-3-6(8)4-2-5/h1-4H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SA} Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis,
  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 三唑类杀菌剂
  • {uni_hamburg} no charge; carbocycle; arom
  • {SNA} Aryl, Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Hydrocarbons, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
  • 600 Series Wastewater Methods, 8000 Series Solidwaste Methods, A-B, Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Bromo,

产品应用

  • 有机合成中间体。

相关文献及参考

  • Short: III/20b
  • Short: III/31b
  • The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).
  • Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).
  • Beilstein: 5,IV,678

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3 Xn
RTECSCY9033750
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Risk Statements
  • R10 Flammable 易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition <;0 <0°C 储存温度2-8℃ 0-6°C
UN Number 1993
Packing GroupIII
Hazard Class3

其他信息

  • 方法二:将干燥的溴素滴加入沸腾的氟苯和吡啶的混合物中，反应产生的溴化氢用水吸收。然后继续加热2h。冷却，加入氢氧化钠溶液，用乙醚萃取，萃取液加无水碳酸钾干燥，分馏。75-90℃的馏分为未反应的氟苯，148-154℃的馏分为对溴氟苯。产率约49%。
  • 下游产品:4-氟-3-(羟甲基)苯基硼酸
  • MSDS 信息:1-Bromo-4-fluorobenzene(460-00-4).msds
  • 上游原料:碳酸钾 --> 溴 --> 氟化苯
  • 用途二:1-溴-4-氟苯是杀菌剂氟硅唑的中间体。
  • Alfa Aesar:1-溴-4-氟苯,99% 1-Bromo-4-fluorobenzene, 99%(460-00-4)
  • Sigma Aldrich:460-00-4(sigmaaldrich)
  • Hazard Note:Flammable/Irritant
  • 方法一:其制备方法是在反应器中加入氟苯和少许铁粉为催化剂，在5～15℃加入溴，而在40℃反应，直到溴消失为止，得到产品。
  • 图谱信息:对溴氟苯(460-00-4)质谱(MS) 对溴氟苯(460-00-4)红外图谱(IR1) 对溴氟苯(460-00-4)核磁图( 13 CNMR)
  • 对溴氟苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010392 对溴氟苯 50ml 198元 2011/04/16 S0675 4-溴氟苯(1mg/ml的甲醇溶液)[水分析用内部标准] 4-Bromofluorobenzene (1mg/ml in Methanol) [Internal standard for Water Analysis] 1ML 198元 2011/04/16 B0884 4-溴氟苯 4-Bromofluorobenzene 25G 202元
  • 海关编码:29036990
  • 不溶于水，溶于甲醇、乙醇、乙醚、丙酮和2-丙醇。
  • 用途一:用于医药、农药的合成
  • 内标液和替代液
  • Acros Organics:对溴氟苯 4-Bromofluorobenzene, 99%(460-00-4)
  • 用途三:有机合成中间体。
  • TCI Shanghai:4-溴氟代苯(1mg/ml的甲醇溶液)[水分析用内部标准] 4-Bromofluorobenzene (1mg/ml in Methanol) [Internal standard for Water Analysis](460-00-4)
  • MOL 文件:460-00-4.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Fluorinated Building Blocks 氟化物砌块
  4. Organic Fluorinated Building Blocks - Fluorinated Building Blocks
  5. Other Fluorinated Organic Building Blocks - Organic Fluorinated Building Blocks
  6. Aryl Fluorinated Building Blocks 芳基氟化物
  7. C6 - Aryl Fluorinated Building Blocks
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  6. C6 - Aryl
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BI - BZ - B
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳香卤代烃
  6. C13 to C37+
  1. Materials Science 材料科学
  2. Building Blocks for Liquid Crystals

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