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分类

• {uni_hamburg} no charge; ester; 1fragment
• Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
• {SNA} Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, E, E-L, EQ - EZ, Environmental Standards, Esters, Nitriles, Volatiles/ Semivolatiles
• {Chemicalbook} 农药中间体: 除草剂中间体: 磺酰脲类除草剂

产品应用

• Ethyl cyanoacetate may be used in the synthesis of ethyl glyoxylate. It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.

相关文献及参考

• Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491: Synthesis, 506 (1985).
• Merck:14,3786
• Short: II/27B
• Merck:14,3786 Beilstein:2,585
• Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).
• For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonyl­methyl­ isocyanide, A14312.
• For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).

安全信息

GHS Symbol

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 5,161,1899

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1410 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 5,161,1899

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1115 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - nausea or vomiting
REFERENCE :
   MELAAD Medicina del Lavoro.  Industrial Medicine.  (Via S. Barnaba, 8, 20122
   Milan, Italy) V.16-    1925-  Volume(issue)/page/year: 47,192,1956

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxiko

其他信息

• TCI Shanghai:氰基乙酸乙酯 Ethyl Cyanoacetate,>;98.0%(GC)(105-56-6)
• {Chemicalbo
• 用途三:该品是医药、染料等精细化工产品的中间体，用于合成酯类、酰胺类、酸类、腈类化合物。日本主要用作氰基丙烯酸酯类快干胶的中间体，用于汽车零件、家用电器组装件的粘接，另外还用于维生素B6、合成染料等领域。氰乙酸乙酯与甲氧基乙酰丙酮及氨水环合可制得5-氰基-6-羟基-4-甲氧甲基-2-甲基吡啶。经硝化、氯化、催化加氢可得3-氨基-5-氨甲基-4-甲氧甲基-2-甲基吡啶。再进一步重氮化、水解、成盐可得微生素B6。
• 用途四:用于有机合成，制药工业，染料工业。
• 灭火剂:雾状水、泡沫、干粉、二氧化碳、砂土
• {Chemic
• Sigma Aldrich
• 防护措施:本品剧毒。主要通过吞入或由皮肤吸收而引起中毒。大鼠经口LD50为400～3200mg/kg。豚鼠经皮LD50＞4ml/kg。其毒性及防护方法参见“氰乙酸”。
• MSDS 信息:氰乙酸乙酯(105-56-6).msds
• 方法一:其制备方法是将氰乙酸与乙醇作用而得。将氰乙酸、乙醇和催化剂硫酸加入反应器回流3h，降温至10℃，然后水洗、分层、干燥，在减压下蒸馏而得成品。 NCCH 2 COOH+C 2 H 5 OH[H 2 SO 4 ]→NCCH 2 COOC 2 H 5 +H 2 O
• 氰乙酸乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80061618 氰乙酸乙酯 500
• 略有气味，微溶于水、碱液、氨水，可混溶于乙醇、乙醚。
• 下游产品:2-乙硫基-4-氨基嘧啶-5-羧酸乙酯 --> 达卡巴嗪 --> 2,4,7-三氨基-6-苯基蝶啶 --> 2-氨基-4,6-二甲基-3-吡啶甲酰胺 --> 别嘌醇 --> 2-巯基-4-羟基-6-氨基嘧啶 --> 3-氨基-2，2-二甲基-1-丙醇 --> 2-氨基-4，5-二甲基噻酚-3-羧酸乙酯 --> 1-环己基-1,2,3,4-四氢-2,4-二氧嘧啶-5-腈 --> 2-氨基-6-甲基-4,5,6,7-四氢-苯并噻吩-3-甲酸乙酯 --> 1,2,3,5-四氢-8-硫杂-5,7-二氮-环戊基[A]茚-4-酮 --> 5,6-二氨基-1-甲基尿嘧啶 --> 2-羟基-4-甲氧甲基-4-甲基烟腈 --> 2-氨基-1,7-二氢-6H-嘌呤-6-酮硫酸盐(2:1) --> 502快干胶 --> 2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯 --> 6-氨基-1-甲基脲嘧啶 --> 2-氨基-4-三氟甲基苯腈 --> 2-氨基环戊并[B!噻吩-3-甲酸乙酯 --> 1-甲基-5-氨基吡唑-4-羧酸乙酯 --> 2-乙基-2-甲基丁二酸 --> 4-氨基-2,6-二羟基嘧啶 --> 分散黄S-3GL --> 盐酸阿米洛利 --> 2-氰基-3-甲基-2-戊烯酸乙酯 --> 4-氨基-6-羟基-2-巯基嘧啶一水物 --> 3-氨基-3-亚氨基-2-苯偶氮基丙酰胺单盐酸盐 --> 6-羟基-2,4,5-三氨基嘧啶 --> 3-乙氧基-3-亚氨基丙酸乙酯盐酸盐
• 可燃性危险特性:明火可燃; 受热或遇酸放出有毒氰化物气体; 遇水放出有毒易燃气体
• 储运特性:库房通风低温干燥; 与食品、氧化剂、酸类分开储运
• 上游原料:乙醇 --> 盐酸 --> 硫酸 --> 氰化钠 --> 氯乙酸 --> 氯乙酸乙酯 --> 氯乙酸钠 --> 氰乙酸 --> 乙酸乙醇 --> 氰乙酸酯
• 用途二:氰乙酸乙酯
• 图谱信息:氰乙酸乙酯(105-56-6)核磁图( 13 CNMR) 氰乙酸乙酯(105-56-6)红外图谱(IR1) 氰乙酸乙酯(105-56-6)红外图谱(IR2) 氰乙酸乙酯(105-56-6)Raman光谱 氰乙酸乙酯(105-56-6)核磁图( 1 HNMR) 氰乙酸乙酯(105-56-6)质谱(MS)
• 方法二:1.氯乙酸酯化氰化法将氯乙酸和乙醇进行酯化反应，生成氯乙酸乙酯，经精制后的氯乙酸乙酯与氰化钠进行氰化反应，制得氰乙酸乙
• F:10