2-Amino-6-methylpyridine 2-氨基-6-甲基吡啶

CAS 1824-81-3 MFCD00006331

化学结构图

1824-81-3
SMILES: Cc1cccc(N)n1

化学属性

Mol. FormulaC6H8N2
Mol. Weight108.14
Density1.068
Flash Point103°(217°F)
TSCAYes
Melting Point>300°C
Boiling Point208-209 °C at 760 mmHg
Stability易吸潮
Solubility易溶于水。

别名和识别编码

Chemical Name2-Amino-6-methylpyridine
Synonym 2-Amino-6-picoline {LY} 2-Amino-6-picoline {} {LY} 2-Amino-6-picoline {} {} {LY} 2-Amino-6-picoline {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-6-picoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00006331
CAS Number1824-81-3
EC Number217-360-1
Beilstein Registry Number22(1)633
PubChem Substance ID15765
Reaxys-RN107048
Chemical Name Translation2-氨基-6-甲基吡啶
Wiswesser Line NotationT6NJ BZ F1
LabNetwork Molecule IDLN00008974
InChIInChI=1S/C6H8N2/c1-5-3-2-4-6(7)8-5/h2-4H,1H3,(H2,7,8)
Canonical SMILESNC1=NC(C)=CC=C1
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分类

  • {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 医药中间体。用于生产萘啶酸，也用于有机合成，制造染料和照相显影剂。

相关文献及参考

  • Short: III/20a
  • Beilstein:22(1)633
  • Short: III/35D3
  • Short: III/35C2

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P301+P316
  • P302+P350
  • P302+P352
  • P302+P352+P310+P361+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSUS1885000
Packing GroupII
UN Number 1759 UN 2811 6.1/PG 3 2811
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H310 Fatal in contact with skin 皮肤接触致命
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AJEBAK Australian Journal of Experimental Biology and Medical Science.
   (Adelaide, S.A., Australia) V.1-64, 1924-86.  Volume(issue)/page/year:
   36,491,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00148

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,841,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,841,1986

其他信息

  • 图谱信息:2-氨基6-甲基吡啶(1824-81-3)红外图谱(IR1) 2-氨基6-甲基吡啶(1824-81-3)核磁图( 13 CNMR) 2-氨基6-甲基吡啶(1824-81-3)质谱(MS) 2-氨基6-甲基吡啶(1824-81-3)核磁图( 1 HNMR) 2-氨基6-甲基吡啶(1824-81-3)红外图谱(IR3) 2-氨基
  • {Che
  • 极易溶于水，能溶于醇、醚、丙酮和苯等多数有机溶剂，溶于氯化溶剂，微溶于二甲苯。有吸湿性。
  • 储运特性:库房通风低温干燥
  • 下游产品:6-甲基-2-甲氧基-3-氨基吡啶 --> 2-甲基-5-硝基-6-氯-3-溴吡啶 --> 2-甲基-5-硝基-6-甲氧基-3-溴吡啶 --> 3-氨基-6-甲氧基吡啶-2-羧酸 --> 2-氟-6-甲基吡啶-3-硼酸 --> 2-氨基-5-硝基-6-甲基吡啶 --> 2-甲基-3-氨基-6-氯吡啶 --> 6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 --> 2-异氰酸根-6-硝基吡啶 --> 2-氨基-5-溴-6-甲基吡啶 --> 2-甲基-6-氨基-5-硝基-3-溴吡啶 --> 6-甲基-2,5-二氨基吡啶 --> 2-氨基-6-硝基吡啶 --> 6-甲基-2-吡啶腈 --> 6-硝基吡啶-2-酰胺 --> 6-硝基吡啶-2-羧酸乙酯 --> 6-叔丁氧羰基氨基吡啶-2-羧酸 --> 6-硝基-2-羧酸吡啶 --> 2-羟基-6-甲基-5-硝基吡啶 --> 2-氨基-3-硝基-6-甲基吡啶 --> 6-甲基吡啶-2-硼酸 --> 5-溴-6-甲基-2(1H)-吡啶酮 --> 6-硝基吡啶-2-碳酰氯 --> 2-氟-6-吡啶甲酰氯 --> 2-氟吡啶-6-羧酸 --> 2-甲基-3,5-二氯-6-氨基吡啶 --> 2-氟-6-甲基吡啶 --> N4,N6-双(4-氟-3-苄基)嘧啶-4,6-二甲酰胺
  • 用途二:医药中间体。用于生产萘啶酸，也用于有机合成，制造染料和照相显影剂。
  • 方法一:由2-甲基吡啶胺化而得。将液氨通入反应罐内，加入硝酸高铁，搅拌下分次缓缓加入小块金属钠，加毕继续搅拌3h。自然排氨，至反应液呈稀浆状，得氨钠液。将无水二甲苯加入氨钠中，
  • MSDS 信息:2-氨基-6-甲基吡啶(1824-81-3).msds
  • 上游原料:钠 --> 氨 --> 4
  • TCI Shanghai:6-氨基-2-甲基吡啶 6-Amino-2-picoline,>;98.0%(GC)(1824-81-3)
  • 极易溶于水，能溶于醇、醚、丙酮和苯等多数
  • 存储注意事项:湿度敏感
  • 毒性分级:高毒
  • 下游产品:6-甲基-2-甲氧基-3-氨基吡啶 --> 2-甲基-5-硝基-6-氯-3-溴吡啶 --> 2-甲基-5-硝基-6-甲氧基-3-溴吡啶 --> 3-氨基-6-甲氧基吡啶-2-羧酸 --> 2-氟-6-甲基吡啶-3-硼酸 --> 2-氨基-5-硝基-6-甲基吡啶 --> 2-甲基-3-氨基-6-氯吡啶 --> 6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 --> 2-异氰酸根-6-硝基吡啶 --> 2-氨基-5-溴-6-甲基吡啶 --> 2-甲基-6-氨基-5-硝基-3-溴吡啶 --> 6-甲基-2,5-二
  • {Chemica
  • 下游产品:6-甲基-2-甲氧基-3-氨基吡啶 --> 2-甲基-5-硝基-6-氯-3-溴吡啶 --> 2-甲基-5-硝基-6-甲氧基-3-溴吡啶 --> 3-氨基-6-甲氧基吡啶-2-羧酸 --> 2-氟-6-甲基吡啶-3-硼酸 --> 2-氨基-5-硝基-6-甲基吡啶 --> 2-甲基-3-氨基-6-氯吡啶 --> 6-甲基-3-硝基-5-溴吡啶-2(1H)-酮 --> 2-异氰酸根-6-硝基吡啶 --> 2-氨基-5-溴-6-甲基吡啶 --> 2-甲基-6-氨基-5-硝基-3-溴吡啶 --> 6-甲基-2,5-二氨基吡啶 --> 2-氨基-6-硝基吡啶 --> 6-甲基-2-吡啶腈 --> 6-硝基吡
  • Acros Organics:2-氨基-6-甲基吡啶 2-Amino-6-picoline, 98%(1824-81-3)
  • {C
  • 敏感性:Hygroscopic
  • {Chemical

系列性分类

  1. C6 - Pyridines
  1. C6 to C7 - Pyridines
  1. C5
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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